DegronMD - P51693(APLP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V223A	TCGA-06-5416	GBM	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.2222
p.V281I	TCGA-13-0894	OV	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.25
p.R203H	TCGA-19-5956	GBM	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0833
p.R203H	TCGA-4Z-AA83	BLCA	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0833
p.R203H	ACH-002021	Endometrial/Uterine Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0833
p.R203C	TCGA-A6-2677	COAD	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0833
p.R203C	TCGA-CV-6960	HNSC	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0833
p.G214V	TCGA-A8-A07G	BRCA	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.6421
p.R229Q	TCGA-AX-A3FT	UCEC	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0556
p.S219Y	TCGA-CJ-4639	KIRC	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.712
p.T277A	TCGA-D1-A15X	UCEC	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1389
p.G293S	TCGA-EJ-7782	PRAD	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2778
p.V280E	TCGA-EO-A3KX	UCEC	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.P211L	TCGA-H9-7775	PRAD	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.3056
p.P211L	SIDM00243	Other Solid Cancers	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.3056
p.P211L	ACH-002288	Embryonal Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.3056
p.P211L	NEC8	testis	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.3056
p.R229P	TCGA-SS-A7HO	COAD	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0556
p.G228E	DO51921	BLCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.0833
p.G208V	DO2870	BRCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.2222
p.S224Y	DO222404	BTCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.1944
p.G296W	DO219737	CESC	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.R223P	DO223705	COAD	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.2222
p.G296A	DO234149	ESAD	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.P212T	DO233882	GACA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.7031
p.P212T	G-361	skin	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.7031
p.V217A	DO10880	GBM	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.6936
p.H301P	DO49049	HNSC	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.0556
p.S213Y	DO17791	KIRC	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.712
p.G276V	DO228948	LICA	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1111
p.G276V	DO229038	LICA	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1111
p.V275I	DO28591	OV	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.0833
p.P210S	DO51473	PACA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.2778
p.P280S	DO49466	PACA	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.P205L	DO36354	PRAD	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.1389
p.P205L	NEC8	testis	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.1389
p.G287S	DO36256	PRAD	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6993
p.P227L	DO229446	SKCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.1111
p.V274E	DO219774	UCEC	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.0556
p.R223Q	DO40801	UCEC	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.2222
p.T215S	SIDM01649	Non-Cancerous	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.7116
p.T215S	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.7116
p.T215S	SIDM01076	B-Lymphoblastic Leukemia	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.7116
p.T215S	SIDM00184	Melanoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.7116
p.P218T	SIDM00857	Melanoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.5919
p.P218T	ACH-000572	Skin Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.5919
p.P218T	G-361	skin	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.5919
p.G214E	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.6087
p.G214E	ACH-002176	Lung Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.6087
p.G214E	NCI-H748	lung	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.6087
p.G282S	SIDM00202	Ewing's Sarcoma	GDSC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2778
p.G282S	ACH-002118	Bone Cancer	CCLE	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2778
p.G282S	EW-3	bone	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2778
p.R289K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6126
p.R289K	ACH-000904	Lung Cancer	CCLE	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6126
p.R289K	ACH-001362	Lung Cancer	CCLE	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6126
p.R289K	NCI-H1770	lung	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6126
p.D215N	MZ7-mel	skin	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation altering degron motif	0.6932
p.Y207D	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.1944
p.R291H	LIM1215	large intestine	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8244
p.E204D	TE-4	oesophagus	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.1111
p.E300K	OCUM-1	stomach	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.0833
p.E207D	HCT-15	large intestine	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.1944
p.G276S	EW-3	bone	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1111
p.R284C	SW1573	lung	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.8301
p.R283K	NCI-H1770	lung	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.3056
p.G208E	NCI-H748	lung	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	212:219	Mutation rewiring degron network	0.2222

Kaplan plot for APLP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APLP1

UniProt ID: P51693

Entrez ID: 333

Protein name: Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for APLP1 in