DegronMD

Uniprot ID: P51693

Source protein: Amyloid beta precursor like protein 1

Source gene: APLP1

Class: DEG_SCF_FBW7_1

Location: 284:291

E3 ligase: FBXW7

DEGRON score: 0.9344

ASA_SCORE: 91.625

COIL: 0.9516

CONS_SCORE: 0.3548

DSS_SCORE: 0.4779

HELIX: 0.0144

FCONS_SCORE: 1.1189

RIG_SCORE: 0.6762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V281I	TCGA-13-0894	OV	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	0.25
p.T277A	TCGA-D1-A15X	UCEC	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	0.1389
p.G293S	TCGA-EJ-7782	PRAD	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	0.2778
p.V280E	TCGA-EO-A3KX	UCEC	TCGA	VTPTPRPT	DEG_SCF_FBW7_1	0.2222
p.G296W	DO219737	CESC	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.1944
p.G296A	DO234149	ESAD	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.1944
p.H301P	DO49049	HNSC	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.0556
p.G276V	DO228948	LICA	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.1111
p.G276V	DO229038	LICA	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.1111
p.V275I	DO28591	OV	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.0833
p.P280S	DO49466	PACA	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.2222
p.G287S	DO36256	PRAD	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.6993
p.V274E	DO219774	UCEC	ICGC	VTPTPRPT	DEG_SCF_FBW7_1	0.0556
p.G282S	SIDM00202	Ewing's Sarcoma	GDSC	VTPTPRPT	DEG_SCF_FBW7_1	0.2778
p.G282S	ACH-002118	Bone Cancer	CCLE	VTPTPRPT	DEG_SCF_FBW7_1	0.2778
p.G282S	EW-3	bone	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	0.2778
p.R289K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	VTPTPRPT	DEG_SCF_FBW7_1	0.6126
p.R289K	ACH-000904	Lung Cancer	CCLE	VTPTPRPT	DEG_SCF_FBW7_1	0.6126
p.R289K	ACH-001362	Lung Cancer	CCLE	VTPTPRPT	DEG_SCF_FBW7_1	0.6126
p.R289K	NCI-H1770	lung	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	0.6126
p.R291H	LIM1215	large_intestine	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	0.8244
p.E300K	OCUM-1	stomach	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	0.0833
p.G276S	EW-3	bone	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	0.1111
p.R284C	SW1573	lung	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	0.8301
p.R283K	NCI-H1770	lung	COSMIC	VTPTPRPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51693	Amyloid beta precursor like protein 1	DEG_SCF_FBW7_1	284:291	VTPTPRPT	FBXW7	0.9344	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons