DegronMD

Uniprot ID: P06400

Source protein: Retinoblastoma-associated protein

Source gene: RB1

Class: DEG_SCF_FBW7_1

Location: 370:377

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 81.85

COIL: 0.8123

CONS_SCORE: 0.4927

DSS_SCORE: 0.4447

HELIX: 0.1454

FCONS_SCORE: 1.2616

RIG_SCORE: 0.7612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q384H	TCGA-AJ-A3EL	UCEC	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	0.1389
p.Q384H	DO41542	UCEC	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	0.1389
p.L385S	TCGA-AX-A1CE	UCEC	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	0.1111
p.L385S	DO42280	UCEC	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	0.1111
p.M379L	TCGA-BR-4361	STAD	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	0.2778
p.M379L	DO38887	STAD	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	0.2778
p.E365Q	TCGA-IN-A6RO	STAD	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	0.1944
p.E365Q	DO51740	STAD	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	0.1944
p.M387I	TCGA-KQ-A41N	BLCA	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	0.0556
p.M387I	DO223588	BLCA	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	0.0556
p.P374A	TCGA-Q1-A73O	CESC	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	0.7503
p.P374A	DO51612	CESC	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	0.7503
p.L385F	DO228815	LICA	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	0.1111
p.M379T	ACH-001669	Leukemia	CCLE	PPHTPVRT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06400	Retinoblastoma-associated protein	DEG_SCF_FBW7_1	370:377	PPHTPVRT	FBXW7	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons