DegronMD - P06400(RB1)

GO - Biological processes (BP): aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; chromatin remodeling [GO:0006338]; digestive tract development [GO:0048565]; enucleate erythrocyte differentiation [GO:0043353]; glial cell apoptotic process [GO:0034349]; hepatocyte apoptotic process [GO:0097284]; heterochromatin assembly [GO:0031507]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; myoblast differentiation [GO:0045445]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron projection development [GO:0031175]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein localization to chromosome, centromeric region [GO:0071459]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of centromere complex assembly [GO:0090230]; regulation of cohesin loading [GO:0071922]; regulation of lipid kinase activity [GO:0043550]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription, DNA-templated [GO:0006355]; sister chromatid biorientation [GO:0031134]; skeletal muscle cell differentiation [GO:0035914]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]; tissue homeostasis [GO:0001894] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q384H	TCGA-AJ-A3EL	UCEC	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.1389
p.Q384H	DO41542	UCEC	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.1389
p.L385S	TCGA-AX-A1CE	UCEC	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.1111
p.L385S	DO42280	UCEC	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.1111
p.M379L	TCGA-BR-4361	STAD	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.2778
p.M379L	DO38887	STAD	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.2778
p.E365Q	TCGA-IN-A6RO	STAD	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.1944
p.E365Q	DO51740	STAD	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.1944
p.M387I	TCGA-KQ-A41N	BLCA	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.0556
p.M387I	DO223588	BLCA	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.0556
p.P374A	TCGA-Q1-A73O	CESC	TCGA	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation altering degron motif	0.7503
p.P374A	DO51612	CESC	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation altering degron motif	0.7503
p.A10S	DO234377	ESAD	ICGC	PPKTPRKT	DEG_SCF_FBW7_1	2:9	Mutation rewiring degron network	0.3056
p.L385F	DO228815	LICA	ICGC	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.1111
p.A11T	DO229242	THCA	ICGC	PPKTPRKT	DEG_SCF_FBW7_1	2:9	Mutation rewiring degron network	0.2778
p.M379T	ACH-001669	Leukemia	CCLE	PPHTPVRT	DEG_SCF_FBW7_1	370:377	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RB1

UniProt ID: P06400

Entrez ID: 5925

Protein name: Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RB1 in