DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PPKTPRKT
Uniprot ID:
P06400
Source protein:
Retinoblastoma-associated protein
Source gene:
RB1
Class:
DEG_SCF_FBW7_1
Location:
2:9
E3 ligase:
FBXW7
DEGRON score:
0.9965
ASA_SCORE:
115.425
COIL:
0.9333
CONS_SCORE:
0.3067
DSS_SCORE:
0.937
HELIX:
0.0558
FCONS_SCORE:
1.0735
RIG_SCORE:
0.6118
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A10S
DO234377
ESAD
ICGC
PPKTPRKT
DEG_SCF_FBW7_1
0.3056
p.A11T
DO229242
THCA
ICGC
PPKTPRKT
DEG_SCF_FBW7_1
0.2778
Drug responses associated with RB1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPKTPRKT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P06400
Retinoblastoma-associated protein
DEG_SCF_FBW7_1
2:9
PPKTPRKT
FBXW7
0.9965
More...