DegronMD

Uniprot ID: Q06889

Source protein: Early growth response protein 3

Source gene: EGR3

Class: DEG_SCF_FBW7_1

Location: 223:230

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 71.3375

COIL: 0.7774

CONS_SCORE: 0.4752

DSS_SCORE: 0.5524

HELIX: 0.143

FCONS_SCORE: 1.0262

RIG_SCORE: 0.7291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R219G	TCGA-85-6561	LUSC	TCGA	PPITPLET	DEG_SCF_FBW7_1	0.2222
p.R219G	DO26518	LUSC	ICGC	PPITPLET	DEG_SCF_FBW7_1	0.2222
p.T230I	TCGA-AA-3947	COAD	TCGA	PPITPLET	DEG_SCF_FBW7_1	0.7078
p.T230I	DO8192	COAD	ICGC	PPITPLET	DEG_SCF_FBW7_1	0.7078
p.F234C	TCGA-EO-A3B0	UCEC	TCGA	PPITPLET	DEG_SCF_FBW7_1	0.2222
p.F234C	DO219773	UCEC	ICGC	PPITPLET	DEG_SCF_FBW7_1	0.2222
p.P224R	TCGA-RP-A693	SKCM	TCGA	PPITPLET	DEG_SCF_FBW7_1	0.6401
p.P224R	DO51268	SKCM	ICGC	PPITPLET	DEG_SCF_FBW7_1	0.6401
p.G214A	DO234303	ESAD	ICGC	PPITPLET	DEG_SCF_FBW7_1	0.0833
p.D216G	DO48232	ESCA	ICGC	PPITPLET	DEG_SCF_FBW7_1	0.1389
p.N221K	DO229026	LICA	ICGC	PPITPLET	DEG_SCF_FBW7_1	0.2778
p.P217S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPITPLET	DEG_SCF_FBW7_1	0.1667
p.P217S	ACH-000938	Leukemia	CCLE	PPITPLET	DEG_SCF_FBW7_1	0.1667
p.P217S	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PPITPLET	DEG_SCF_FBW7_1	0.1667
p.H240P	ACH-000833	Sarcoma	CCLE	PPITPLET	DEG_SCF_FBW7_1	0.0556
p.H237Y	AM-38	central_nervous_system	COSMIC	PPITPLET	DEG_SCF_FBW7_1	0.25
p.R235Q	SW684	soft_tissue	COSMIC	PPITPLET	DEG_SCF_FBW7_1	0.3056
p.R221H	RL95-2	endometrium	COSMIC	PPITPLET	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06889	Early growth response protein 3	DEG_SCF_FBW7_1	223:230	PPITPLET	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons