DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPITPLET
Uniprot ID:
Q06889
Source protein:
Early growth response protein 3
Source gene:
EGR3
Class:
DEG_SCF_FBW7_1
Location:
223:230
E3 ligase:
FBXW7
DEGRON score:
0.9975
ASA_SCORE:
71.3375
COIL:
0.7774
CONS_SCORE:
0.4752
DSS_SCORE:
0.5524
HELIX:
0.143
FCONS_SCORE:
1.0262
RIG_SCORE:
0.7291
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T230I
TCGA-AA-3947
COAD
TCGA
PPITPLET
DEG_SCF_FBW7_1
0.7078
p.T230I
DO8192
COAD
ICGC
PPITPLET
DEG_SCF_FBW7_1
0.7078
p.P224R
TCGA-RP-A693
SKCM
TCGA
PPITPLET
DEG_SCF_FBW7_1
0.6401
p.P224R
DO51268
SKCM
ICGC
PPITPLET
DEG_SCF_FBW7_1
0.6401
p.R235Q
SW684
soft_tissue
COSMIC
PPITPLET
DEG_SCF_FBW7_1
0.3056
p.N221K
DO229026
LICA
ICGC
PPITPLET
DEG_SCF_FBW7_1
0.2778
p.R221H
RL95-2
endometrium
COSMIC
PPITPLET
DEG_SCF_FBW7_1
0.2778
p.H237Y
AM-38
central_nervous_system
COSMIC
PPITPLET
DEG_SCF_FBW7_1
0.25
p.R219G
TCGA-85-6561
LUSC
TCGA
PPITPLET
DEG_SCF_FBW7_1
0.2222
p.R219G
DO26518
LUSC
ICGC
PPITPLET
DEG_SCF_FBW7_1
0.2222
p.F234C
TCGA-EO-A3B0
UCEC
TCGA
PPITPLET
DEG_SCF_FBW7_1
0.2222
p.F234C
DO219773
UCEC
ICGC
PPITPLET
DEG_SCF_FBW7_1
0.2222
p.P217S
SIDM00429
B-Lymphoblastic Leukemia
GDSC
PPITPLET
DEG_SCF_FBW7_1
0.1667
p.P217S
ACH-000938
Leukemia
CCLE
PPITPLET
DEG_SCF_FBW7_1
0.1667
p.P217S
NALM-6
haematopoietic_and_lymphoid_tissue
COSMIC
PPITPLET
DEG_SCF_FBW7_1
0.1667
p.D216G
DO48232
ESCA
ICGC
PPITPLET
DEG_SCF_FBW7_1
0.1389
p.G214A
DO234303
ESAD
ICGC
PPITPLET
DEG_SCF_FBW7_1
0.0833
p.H240P
ACH-000833
Sarcoma
CCLE
PPITPLET
DEG_SCF_FBW7_1
0.0556
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Drug responses associated with EGR3 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PPITPLET
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q06889
Early growth response protein 3
DEG_SCF_FBW7_1
223:230
PPITPLET
FBXW7
0.9975
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