DegronMD - Q06889(EGR3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H275Q	TCGA-39-5034	LUSC	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.25
p.H275Q	DO26854	LUSC	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.25
p.S266R	TCGA-44-7670	LUAD	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation altering degron motif	0.6316
p.S266R	DO23555	LUAD	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation altering degron motif	0.6316
p.R219G	TCGA-85-6561	LUSC	TCGA	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.2222
p.R219G	DO26518	LUSC	ICGC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.2222
p.T230I	TCGA-AA-3947	COAD	TCGA	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation altering degron motif	0.7078
p.T230I	DO8192	COAD	ICGC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation altering degron motif	0.7078
p.R257G	TCGA-BG-A0M8	UCEC	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1111
p.R257G	DO42488	UCEC	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1111
p.F234C	TCGA-EO-A3B0	UCEC	TCGA	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.2222
p.F234C	DO219773	UCEC	ICGC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.2222
p.P224R	TCGA-RP-A693	SKCM	TCGA	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation altering degron motif	0.6401
p.P224R	DO51268	SKCM	ICGC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation altering degron motif	0.6401
p.E280K	TCGA-XF-AAMG	BLCA	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1111
p.E280K	DO219049	BLCA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1111
p.G214A	DO234303	ESAD	ICGC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.0833
p.D216G	DO48232	ESCA	ICGC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.1389
p.R259H	DO233103	GACA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1667
p.R259H	DO233629	GACA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1667
p.R259H	SIDM01088	Endometrial Carcinoma	GDSC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1667
p.R259H	ACH-000965	Endometrial/Uterine Cancer	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1667
p.R259H	RL95-2	endometrium	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.1667
p.R264W	DO233888	GACA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.3056
p.N221K	DO229026	LICA	ICGC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.2778
p.R273Q	SIDM01175	Other Sarcomas	GDSC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.3056
p.R273Q	ACH-002309	Sarcoma	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.3056
p.R273Q	SW684	soft tissue	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.3056
p.H275Y	SIDM00492	Glioblastoma	GDSC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.25
p.H275Y	ACH-000269	Brain Cancer	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.25
p.H275Y	AM-38	central nervous system	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.25
p.P217S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.1667
p.P217S	ACH-000938	Leukemia	CCLE	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.1667
p.P217S	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.1667
p.G281D	ACH-000774	Lung Cancer	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.0833
p.H240P	ACH-000833	Sarcoma	CCLE	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.0556
p.T262M	OVK-18	ovary	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation rewiring degron network	0.25
p.H237Y	AM-38	central nervous system	COSMIC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation substituting flanking lysine	0.25
p.R235Q	SW684	soft tissue	COSMIC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation substituting flanking lysine	0.3056
p.R221H	RL95-2	endometrium	COSMIC	PPITPLET	DEG_SCF_FBW7_1	223:230	Mutation rewiring degron network	0.2778
p.R270Q	LXF-289	lung	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	265:272	Mutation altering degron motif	0.7329

Kaplan plot for EGR3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EGR3

UniProt ID: Q06889

Entrez ID: 1960

Protein name: Early growth response protein 3 (EGR-3) (Zinc finger protein pilot)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EGR3 in