DegronMD

Uniprot ID: Q06889

Source protein: Early growth response protein 3

Source gene: EGR3

Class: DEG_SCF_FBW7_2

Location: 265:272

E3 ligase: FBXW7

DEGRON score: 0.5338

ASA_SCORE: 84.3

COIL: 0.8903

CONS_SCORE: 0.6396

DSS_SCORE: 0.6691

HELIX: 0.0116

FCONS_SCORE: 1.0588

RIG_SCORE: 0.5808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H275Q	TCGA-39-5034	LUSC	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	0.25
p.H275Q	DO26854	LUSC	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	0.25
p.S266R	TCGA-44-7670	LUAD	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	0.6316
p.S266R	DO23555	LUAD	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	0.6316
p.R257G	TCGA-BG-A0M8	UCEC	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	0.1111
p.R257G	DO42488	UCEC	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	0.1111
p.E280K	TCGA-XF-AAMG	BLCA	TCGA	PSKTPLHE	DEG_SCF_FBW7_2	0.1111
p.E280K	DO219049	BLCA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	0.1111
p.R259H	DO233103	GACA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	0.1667
p.R259H	DO233629	GACA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	0.1667
p.R259H	SIDM01088	Endometrial Carcinoma	GDSC	PSKTPLHE	DEG_SCF_FBW7_2	0.1667
p.R259H	ACH-000965	Endometrial/Uterine Cancer	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	0.1667
p.R259H	RL95-2	endometrium	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	0.1667
p.R264W	DO233888	GACA	ICGC	PSKTPLHE	DEG_SCF_FBW7_2	0.3056
p.R273Q	SIDM01175	Other Sarcomas	GDSC	PSKTPLHE	DEG_SCF_FBW7_2	0.3056
p.R273Q	ACH-002309	Sarcoma	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	0.3056
p.R273Q	SW684	soft_tissue	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	0.3056
p.H275Y	SIDM00492	Glioblastoma	GDSC	PSKTPLHE	DEG_SCF_FBW7_2	0.25
p.H275Y	ACH-000269	Brain Cancer	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	0.25
p.H275Y	AM-38	central_nervous_system	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	0.25
p.G281D	ACH-000774	Lung Cancer	CCLE	PSKTPLHE	DEG_SCF_FBW7_2	0.0833
p.T262M	OVK-18	ovary	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	0.25
p.R270Q	LXF-289	lung	COSMIC	PSKTPLHE	DEG_SCF_FBW7_2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06889	Early growth response protein 3	DEG_SCF_FBW7_2	265:272	PSKTPLHE	FBXW7	0.5338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons