DegronMD

Uniprot ID: Q9BZE3

Source protein: BarH-like 1 homeobox protein

Source gene: BARHL1

Class: DEG_SIAH_1

Location: 314:322

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9971

ASA_SCORE: 72.7889

COIL: 0.9258

CONS_SCORE: 0.4791

DSS_SCORE: 0.6706

HELIX: 0.0227

FCONS_SCORE: 1.0544

RIG_SCORE: 0.6777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L313P	DO227802	COCA	ICGC	PPLAGVLPR	DEG_SIAH_1	0.3056
p.V319I	DO38663	STAD	ICGC	PPLAGVLPR	DEG_SIAH_1	0.7076
p.P309S	DO229151	THCA	ICGC	PPLAGVLPR	DEG_SIAH_1	0.1944
p.L316M	SIDM00371	Pancreatic Carcinoma	GDSC	PPLAGVLPR	DEG_SIAH_1	0.5999
p.L316M	SIDM00552	Rhabdomyosarcoma	GDSC	PPLAGVLPR	DEG_SIAH_1	0.5999
p.L316M	ACH-000607	Rhabdoid	CCLE	PPLAGVLPR	DEG_SIAH_1	0.5999
p.L316M	ACH-001421	Eye Cancer	CCLE	PPLAGVLPR	DEG_SIAH_1	0.5999
p.P315T	SIDM00279	Gastric Carcinoma	GDSC	PPLAGVLPR	DEG_SIAH_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZE3	BarH-like 1 homeobox protein	DEG_SIAH_1	314:322	PPLAGVLPR	SIAH1,SIAH2,SIAH3	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons