DegronMD

Uniprot ID: Q8N693

Source protein: Homeobox protein ESX1

Source gene: ESX1

Class: DEG_SIAH_1

Location: 298:306

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.6469

ASA_SCORE: 87.3

COIL: 0.9702

CONS_SCORE: 0.419

DSS_SCORE: 0.2441

HELIX: 0.01

FCONS_SCORE: 0.9848

RIG_SCORE: 0.5906

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R290H	TCGA-32-2616	GBM	TCGA	PPMAPVPPW	DEG_SIAH_1	0.1111
p.R290H	DO13462	GBM	ICGC	PPMAPVPPW	DEG_SIAH_1	0.1111
p.P299H	TCGA-56-A62T	LUSC	TCGA	PPMAPVPPW	DEG_SIAH_1	0.7694
p.P299H	DO219144	LUSC	ICGC	PPMAPVPPW	DEG_SIAH_1	0.7694
p.G288R	TCGA-AP-A0LM	UCEC	TCGA	PPMAPVPPW	DEG_SIAH_1	0.0556
p.G288R	DO43306	UCEC	ICGC	PPMAPVPPW	DEG_SIAH_1	0.0556
p.A292T	TCGA-B5-A3FC	UCEC	TCGA	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	DO41871	UCEC	ICGC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	SIDM00304	Ovarian Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	SIDM01194	Hepatocellular Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	SIDM00375	Head and Neck Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	SIDM00410	Other Blood Cancers	GDSC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	SIDM00247	Gastric Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	MKN45	stomach	COSMIC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.A292T	SNU-449	liver	COSMIC	PPMAPVPPW	DEG_SIAH_1	0.1667
p.R290C	TCGA-BR-4368	STAD	TCGA	PPMAPVPPW	DEG_SIAH_1	0.1111
p.R290C	DO38715	STAD	ICGC	PPMAPVPPW	DEG_SIAH_1	0.1111
p.R290C	SIDM00189	Melanoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.1111
p.R290C	SIDM00200	Ewing's Sarcoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.1111
p.R290C	ACH-002098	Skin Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	0.1111
p.R290C	ACH-002112	Bone Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	0.1111
p.P289S	TCGA-BR-8361	STAD	TCGA	PPMAPVPPW	DEG_SIAH_1	0.0833
p.P289S	DO48032	STAD	ICGC	PPMAPVPPW	DEG_SIAH_1	0.0833
p.P289S	SIDM01156	Small Cell Lung Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.0833
p.P289S	ACH-000890	Lung Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	0.0833
p.P305H	TCGA-D7-A4YY	STAD	TCGA	PPMAPVPPW	DEG_SIAH_1	0.7694
p.P305H	DO47733	STAD	ICGC	PPMAPVPPW	DEG_SIAH_1	0.7694
p.P298L	TCGA-FS-A4FB	SKCM	TCGA	PPMAPVPPW	DEG_SIAH_1	0.6471
p.P298L	DO37790	SKCM	ICGC	PPMAPVPPW	DEG_SIAH_1	0.6471
p.P293L	TCGA-WE-A8ZX	SKCM	TCGA	PPMAPVPPW	DEG_SIAH_1	0.1944
p.P293L	DO51291	SKCM	ICGC	PPMAPVPPW	DEG_SIAH_1	0.1944
p.G315W	TCGA-ZH-A8Y6	CHOL	TCGA	PPMAPVPPW	DEG_SIAH_1	0.0833
p.G315W	DO229059	LICA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.0833
p.P305T	DO225122	BRCA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.7031
p.P305T	DO231140	LAML	ICGC	PPMAPVPPW	DEG_SIAH_1	0.7031
p.P305T	DO23382	LINC	ICGC	PPMAPVPPW	DEG_SIAH_1	0.7031
p.P305T	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	0.7031
p.V303L	DO52549	BRCA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.6765
p.P302H	DO222765	COCA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.6583
p.P316L	DO233869	GACA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.0556
p.M309I	DO228924	LICA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.25
p.P298T	DO228948	LICA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.5919
p.W297L	DO229240	THCA	ICGC	PPMAPVPPW	DEG_SIAH_1	0.3056
p.A301V	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.6936
p.A310V	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPMAPVPPW	DEG_SIAH_1	0.2222
p.A310V	ACH-000874	Leukemia	CCLE	PPMAPVPPW	DEG_SIAH_1	0.2222
p.P305L	SIDM00980	Gastric Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	0.7582
p.P305L	ACH-000948	Gastric Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPMAPVPPW

Degron related mutations and impact score

Drug responses associated with ESX1 mutations

All proteins holding degron of PPMAPVPPW

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N693	Homeobox protein ESX1	DEG_SIAH_1	298:306	PPMAPVPPW	SIAH1,SIAH2,SIAH3	0.6469	More...