DegronMD - Q8N693(ESX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R290H	TCGA-32-2616	GBM	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.R290H	DO13462	GBM	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.P347R	TCGA-4V-A9QS	THYM	TCGA	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1944
p.P347R	TCGA-DX-A6Z2	SARC	TCGA	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1944
p.P347R	DO229374	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1944
p.P347R	DO229383	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1944
p.P347R	DO229387	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1944
p.P347R	DO51000	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1944
p.P347R	DO220019	SARC	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1944
p.P299H	TCGA-56-A62T	LUSC	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7694
p.P299H	DO219144	LUSC	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7694
p.R329P	TCGA-59-A5PD	OV	TCGA	PPMARVPPG	DEG_SIAH_1	325:333	Mutation altering degron motif	0.6401
p.R329P	TCGA-C5-A7X8	CESC	TCGA	PPMARVPPG	DEG_SIAH_1	325:333	Mutation altering degron motif	0.6401
p.R329P	DO49895	CESC	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation altering degron motif	0.6401
p.R329P	DO50085	OV	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation altering degron motif	0.6401
p.P323T	TCGA-A6-2677	COAD	TCGA	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.P323T	TCGA-VS-A94W	CESC	TCGA	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.P323T	DO222756	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.P323T	DO219726	CESC	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.P323T	DO8288	COAD	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.P323T	DO45243	LIRI	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.G288R	TCGA-AP-A0LM	UCEC	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0556
p.G288R	DO43306	UCEC	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0556
p.A292T	TCGA-B5-A3FC	UCEC	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	DO41871	UCEC	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	SIDM00304	Ovarian Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	SIDM01194	Hepatocellular Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	SIDM00375	Head and Neck Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	SIDM00410	Other Blood Cancers	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	SIDM00247	Gastric Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	MKN45	stomach	COSMIC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	YT	haematopoietic and lymphoid tissue	COSMIC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.A292T	SNU-449	liver	COSMIC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1667
p.R290C	TCGA-BR-4368	STAD	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.R290C	DO38715	STAD	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.R290C	SIDM00189	Melanoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.R290C	SIDM00200	Ewing's Sarcoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.R290C	ACH-002098	Skin Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.R290C	ACH-002112	Bone Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1111
p.P289S	TCGA-BR-8361	STAD	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0833
p.P289S	DO48032	STAD	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0833
p.P289S	SIDM01156	Small Cell Lung Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0833
p.P289S	ACH-000890	Lung Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0833
p.P305H	TCGA-D7-A4YY	STAD	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7694
p.P305H	DO47733	STAD	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7694
p.P298L	TCGA-FS-A4FB	SKCM	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.6471
p.P298L	DO37790	SKCM	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.6471
p.P293L	TCGA-WE-A8ZX	SKCM	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1944
p.P293L	DO51291	SKCM	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.1944
p.R338P	TCGA-YT-A95D	THYM	TCGA	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.R338P	DO229346	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.R338P	DO51527	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.R338P	DO51506	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.R338P	DO51484	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.R338P	DO51465	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.R338P	DO221546	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.R338P	DO228015	SKCA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6401
p.G315W	TCGA-ZH-A8Y6	CHOL	TCGA	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0833
p.G315W	TCGA-ZH-A8Y6	CHOL	TCGA	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.0556
p.G315W	DO229059	LICA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0833
p.G315W	DO229059	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.0556
p.P305T	DO225122	BRCA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7031
p.P305T	DO231140	LAML	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7031
p.P305T	DO23382	LINC	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7031
p.P305T	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7031
p.V303L	DO52549	BRCA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.6765
p.P320R	DO222486	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1944
p.P320R	DO222583	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1944
p.P320R	DO222586	ESCA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1944
p.P320R	DO228983	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1944
p.P320R	DO229056	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1944
p.P320R	DO23480	LINC	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1944
p.P320R	DO218896	SKCA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1944
p.P302H	DO222765	COCA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.6583
p.P316L	DO233869	GACA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.0556
p.P316L	DO233869	GACA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.0833
p.L348V	DO229486	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1667
p.L348V	DO51000	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1667
p.L348V	DO23370	LINC	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1667
p.M309I	DO228924	LICA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.25
p.P298T	DO228948	LICA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.5919
p.G324W	DO229044	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.3056
p.G324W	DO229044	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.0556
p.V339L	DO23406	LINC	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V339L	DO51527	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V339L	DO51506	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V339L	DO51484	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V339L	DO51481	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V339L	DO221546	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V339L	DO232531	PBCA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V339L	DO232532	PBCA	ICGC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6765
p.V330G	DO222491	MELA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation altering degron motif	0.7532
p.A319V	DO35442	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.1667
p.W297L	DO229240	THCA	ICGC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.3056
p.P323H	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.P323H	NCI-H2172	lung	COSMIC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation rewiring degron network	0.2778
p.A337V	SIDM01137	Pancreatic Carcinoma	GDSC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6936
p.A337V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6936
p.A337V	ACH-001735	Leukemia	CCLE	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.6936
p.P332T	SIDM00454	Rhabdomyosarcoma	GDSC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation altering degron motif	0.7031
p.P332T	RH-18	soft tissue	COSMIC	PPMARVPPG	DEG_SIAH_1	325:333	Mutation altering degron motif	0.7031
p.A337T	SIDM00074	Burkitt's Lymphoma	GDSC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.7139
p.A337T	ACH-000402	Lymphoma	CCLE	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.7139
p.A337T	BL-70	haematopoietic and lymphoid tissue	COSMIC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation altering degron motif	0.7139
p.A301V	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.6936
p.A310V	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.2222
p.A310V	ACH-000874	Leukemia	CCLE	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation rewiring degron network	0.2222
p.P305L	SIDM00980	Gastric Carcinoma	GDSC	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7582
p.P305L	ACH-000948	Gastric Cancer	CCLE	PPMAPVPPW	DEG_SIAH_1	298:306	Mutation altering degron motif	0.7582
p.L348R	ACH-001550	Skin Cancer	CCLE	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1667
p.L348R	MCC13	skin	COSMIC	PPMARVPPG	DEG_SIAH_1	334:342	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ESX1

UniProt ID: Q8N693

Entrez ID: 80712

Protein name: Homeobox protein ESX1 (Extraembryonic, spermatogenesis, homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ESX1 in