DegronMD

Uniprot ID: Q8N693

Source protein: Homeobox protein ESX1

Source gene: ESX1

Class: DEG_SIAH_1

Location: 334:342

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9747

ASA_SCORE: 82.9889

COIL: 0.9411

CONS_SCORE: 0.5226

DSS_SCORE: 0.5238

HELIX: 0.0162

FCONS_SCORE: 1.132

RIG_SCORE: 0.505

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P347R	TCGA-4V-A9QS	THYM	TCGA	PPMARVPPG	DEG_SIAH_1	0.1944
p.P347R	TCGA-DX-A6Z2	SARC	TCGA	PPMARVPPG	DEG_SIAH_1	0.1944
p.P347R	DO229374	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P347R	DO229383	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P347R	DO229387	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P347R	DO51000	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P347R	DO220019	SARC	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.R338P	TCGA-YT-A95D	THYM	TCGA	PPMARVPPG	DEG_SIAH_1	0.6401
p.R338P	DO229346	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.R338P	DO51527	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.R338P	DO51506	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.R338P	DO51484	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.R338P	DO51465	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.R338P	DO221546	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.R338P	DO228015	SKCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.L348V	DO229486	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	0.1667
p.L348V	DO51000	LAML	ICGC	PPMARVPPG	DEG_SIAH_1	0.1667
p.L348V	DO23370	LINC	ICGC	PPMARVPPG	DEG_SIAH_1	0.1667
p.G324W	DO229044	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	0.0556
p.V339L	DO23406	LINC	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.V339L	DO51527	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.V339L	DO51506	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.V339L	DO51484	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.V339L	DO51481	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.V339L	DO221546	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.V339L	DO232531	PBCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.V339L	DO232532	PBCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.6765
p.A337V	SIDM01137	Pancreatic Carcinoma	GDSC	PPMARVPPG	DEG_SIAH_1	0.6936
p.A337V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PPMARVPPG	DEG_SIAH_1	0.6936
p.A337V	ACH-001735	Leukemia	CCLE	PPMARVPPG	DEG_SIAH_1	0.6936
p.A337T	SIDM00074	Burkitt's Lymphoma	GDSC	PPMARVPPG	DEG_SIAH_1	0.7139
p.A337T	ACH-000402	Lymphoma	CCLE	PPMARVPPG	DEG_SIAH_1	0.7139
p.A337T	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	PPMARVPPG	DEG_SIAH_1	0.7139
p.L348R	ACH-001550	Skin Cancer	CCLE	PPMARVPPG	DEG_SIAH_1	0.1667
p.L348R	MCC13	skin	COSMIC	PPMARVPPG	DEG_SIAH_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPMARVPPG

Degron related mutations and impact score

Drug responses associated with ESX1 mutations

All proteins holding degron of PPMARVPPG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N693	Homeobox protein ESX1	DEG_SIAH_1	325:333	PPMARVPPG	SIAH1,SIAH2,SIAH3	0.9178	More...
Q8N693	Homeobox protein ESX1	DEG_SIAH_1	334:342	PPMARVPPG	SIAH1,SIAH2,SIAH3	0.9747	More...