DegronMD

Uniprot ID: Q8N693

Source protein: Homeobox protein ESX1

Source gene: ESX1

Class: DEG_SIAH_1

Location: 325:333

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9178

ASA_SCORE: 78.2111

COIL: 0.9467

CONS_SCORE: 0.4332

DSS_SCORE: 0.4816

HELIX: 0.0198

FCONS_SCORE: 0.9188

RIG_SCORE: 0.5166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R329P	TCGA-59-A5PD	OV	TCGA	PPMARVPPG	DEG_SIAH_1	0.6401
p.R329P	TCGA-C5-A7X8	CESC	TCGA	PPMARVPPG	DEG_SIAH_1	0.6401
p.R329P	DO49895	CESC	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.R329P	DO50085	OV	ICGC	PPMARVPPG	DEG_SIAH_1	0.6401
p.P323T	TCGA-A6-2677	COAD	TCGA	PPMARVPPG	DEG_SIAH_1	0.2778
p.P323T	TCGA-VS-A94W	CESC	TCGA	PPMARVPPG	DEG_SIAH_1	0.2778
p.P323T	DO222756	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.2778
p.P323T	DO219726	CESC	ICGC	PPMARVPPG	DEG_SIAH_1	0.2778
p.P323T	DO8288	COAD	ICGC	PPMARVPPG	DEG_SIAH_1	0.2778
p.P323T	DO45243	LIRI	ICGC	PPMARVPPG	DEG_SIAH_1	0.2778
p.G315W	TCGA-ZH-A8Y6	CHOL	TCGA	PPMARVPPG	DEG_SIAH_1	0.0556
p.G315W	DO229059	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	0.0556
p.P320R	DO222486	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P320R	DO222583	BTCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P320R	DO222586	ESCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P320R	DO228983	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P320R	DO229056	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P320R	DO23480	LINC	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P320R	DO218896	SKCA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1944
p.P316L	DO233869	GACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.0833
p.G324W	DO229044	LICA	ICGC	PPMARVPPG	DEG_SIAH_1	0.3056
p.V330G	DO222491	MELA	ICGC	PPMARVPPG	DEG_SIAH_1	0.7532
p.A319V	DO35442	PACA	ICGC	PPMARVPPG	DEG_SIAH_1	0.1667
p.P323H	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPMARVPPG	DEG_SIAH_1	0.2778
p.P323H	NCI-H2172	lung	COSMIC	PPMARVPPG	DEG_SIAH_1	0.2778
p.P332T	SIDM00454	Rhabdomyosarcoma	GDSC	PPMARVPPG	DEG_SIAH_1	0.7031
p.P332T	RH-18	soft_tissue	COSMIC	PPMARVPPG	DEG_SIAH_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons