DegronMD

Uniprot ID: Q15459

Source protein: Splicing factor 3A subunit 1

Source gene: SF3A1

Class: DEG_Kelch_actinfilin_1

Location: 644:648

E3 ligase: CUL3,KLHL17

DEGRON score: 0.7778

ASA_SCORE: 87

COIL: 0.92

CONS_SCORE: 0.2744

DSS_SCORE: 0.2971

HELIX: 0.0162

FCONS_SCORE: 0.9029

RIG_SCORE: 0.6448

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M646L	DO229167	THCA	ICGC	PPMIV	DEG_Kelch_actinfilin_1	0.711
p.P644T	DO229022	LICA	ICGC	PPMIV	DEG_Kelch_actinfilin_1	0.7031
p.P649T	ACH-002059	Leukemia	CCLE	PPMIV	DEG_Kelch_actinfilin_1	0.3056
p.R642P	DO229163	THCA	ICGC	PPMIV	DEG_Kelch_actinfilin_1	0.2778
p.P636T	TCGA-EB-A24C	SKCM	TCGA	PPMIV	DEG_Kelch_actinfilin_1	0.1111
p.P636T	DO37438	SKCM	ICGC	PPMIV	DEG_Kelch_actinfilin_1	0.1111
p.A635V	TCGA-AA-3663	COAD	TCGA	PPMIV	DEG_Kelch_actinfilin_1	0.0833
p.A635V	DO9346	COAD	ICGC	PPMIV	DEG_Kelch_actinfilin_1	0.0833
p.P657L	TCGA-W3-AA21	SKCM	TCGA	PPMIV	DEG_Kelch_actinfilin_1	0.0833
p.P657L	DO51278	SKCM	ICGC	PPMIV	DEG_Kelch_actinfilin_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15459	Splicing factor 3A subunit 1	DEG_Kelch_actinfilin_1	644:648	PPMIV	CUL3,KLHL17	0.7778	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons