DegronMD

Uniprot ID: P18825

Source protein: Alpha-2C adrenergic receptor

Source gene: ADRA2C

Class: DEG_SIAH_1

Location: 278:286

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.6846

ASA_SCORE: 85.7111

COIL: 0.8707

CONS_SCORE: 0.2743

DSS_SCORE: 0.7174

HELIX: 0.1108

FCONS_SCORE: 1.0244

RIG_SCORE: 0.6245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P278S	DO222874	COCA	ICGC	PPPADVEPD	DEG_SIAH_1	0.5641
p.A270T	ACH-000528	Lung Cancer	CCLE	PPPADVEPD	DEG_SIAH_1	0.1111
p.D286N	ACH-000932	Gastric Cancer	CCLE	PPPADVEPD	DEG_SIAH_1	0.5821
p.P285L	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPPADVEPD	DEG_SIAH_1	0.7582
p.G274R	ACH-001382	Pancreatic Cancer	CCLE	PPPADVEPD	DEG_SIAH_1	0.2222
p.E287D	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPPADVEPD	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18825	Alpha-2C adrenergic receptor	DEG_SIAH_1	278:286	PPPADVEPD	SIAH1,SIAH2,SIAH3	0.6846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons