DegronMD

Uniprot ID: P42768

Source protein: Wiskott-Aldrich syndrome protein

Source gene: WAS

Class: DEG_SCF_FBW7_2

Location: 161:168

E3 ligase: FBXW7

DEGRON score: 0.5603

ASA_SCORE: 84.5125

COIL: 0.8733

CONS_SCORE: 0.2531

DSS_SCORE: 0.9087

HELIX: 0.1153

FCONS_SCORE: 0.8771

RIG_SCORE: 0.533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R156I	TCGA-AX-A2HC	UCEC	TCGA	PPPTPANE	DEG_SCF_FBW7_2	0.1944
p.R156I	TCGA-DF-A2KU	UCEC	TCGA	PPPTPANE	DEG_SCF_FBW7_2	0.1944
p.R156I	DO223286	UCEC	ICGC	PPPTPANE	DEG_SCF_FBW7_2	0.1944
p.R156I	DO41572	UCEC	ICGC	PPPTPANE	DEG_SCF_FBW7_2	0.1944
p.R157H	TCGA-BR-8295	STAD	TCGA	PPPTPANE	DEG_SCF_FBW7_2	0.2222
p.R157H	DO38579	STAD	ICGC	PPPTPANE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42768	Wiskott-Aldrich syndrome protein	DEG_SCF_FBW7_2	161:168	PPPTPANE	FBXW7	0.5603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons