DegronMD - P42768(WAS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R156I	TCGA-AX-A2HC	UCEC	TCGA	PPPTPANE	DEG_SCF_FBW7_2	161:168	Mutation rewiring degron network	0.1944
p.R156I	TCGA-DF-A2KU	UCEC	TCGA	PPPTPANE	DEG_SCF_FBW7_2	161:168	Mutation rewiring degron network	0.1944
p.R156I	DO223286	UCEC	ICGC	PPPTPANE	DEG_SCF_FBW7_2	161:168	Mutation rewiring degron network	0.1944
p.R156I	DO41572	UCEC	ICGC	PPPTPANE	DEG_SCF_FBW7_2	161:168	Mutation rewiring degron network	0.1944
p.Q185L	TCGA-B5-A3FC	UCEC	TCGA	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1389
p.Q185L	DO41871	UCEC	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1389
p.R157H	TCGA-BR-8295	STAD	TCGA	PPPTPANE	DEG_SCF_FBW7_2	161:168	Mutation rewiring degron network	0.2222
p.R157H	DO38579	STAD	ICGC	PPPTPANE	DEG_SCF_FBW7_2	161:168	Mutation rewiring degron network	0.2222
p.H180Y	TCGA-BR-8360	STAD	TCGA	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.2778
p.H180Y	DO47745	STAD	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.2778
p.D184Y	TCGA-BS-A0UF	UCEC	TCGA	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1667
p.D184Y	DO41488	UCEC	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1667
p.G173V	DO233852	GACA	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.6421
p.P175Q	DO220878	MELA	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.5924
p.P181L	DO220908	MELA	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.25
p.H180N	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.2778
p.H180N	SIDM00426	Rhabdomyosarcoma	GDSC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.2778
p.H180N	SIDM01772	Mesothelioma	GDSC	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.2778
p.G173E	ACH-001521	Skin Cancer	CCLE	RRGGLPPLP	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.6087

Kaplan plot for WAS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WAS

UniProt ID: P42768

Entrez ID: 7454

Protein name: Wiskott-Aldrich syndrome protein (WASp)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WAS in