DegronMD

Uniprot ID: P42768

Source protein: Wiskott-Aldrich syndrome protein

Source gene: WAS

Class: DEG_APCC_DBOX_1

Location: 170:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9811

ASA_SCORE: 88.0556

COIL: 0.9188

CONS_SCORE: 0.2739

DSS_SCORE: 0.8548

HELIX: 0.0493

FCONS_SCORE: 1.2772

RIG_SCORE: 0.5439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q185L	TCGA-B5-A3FC	UCEC	TCGA	RRGGLPPLP	DEG_APCC_DBOX_1	0.1389
p.Q185L	DO41871	UCEC	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	0.1389
p.H180Y	TCGA-BR-8360	STAD	TCGA	RRGGLPPLP	DEG_APCC_DBOX_1	0.2778
p.H180Y	DO47745	STAD	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	0.2778
p.D184Y	TCGA-BS-A0UF	UCEC	TCGA	RRGGLPPLP	DEG_APCC_DBOX_1	0.1667
p.D184Y	DO41488	UCEC	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	0.1667
p.G173V	DO233852	GACA	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	0.6421
p.P175Q	DO220878	MELA	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	0.5924
p.P181L	DO220908	MELA	ICGC	RRGGLPPLP	DEG_APCC_DBOX_1	0.25
p.H180N	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	RRGGLPPLP	DEG_APCC_DBOX_1	0.2778
p.H180N	SIDM00426	Rhabdomyosarcoma	GDSC	RRGGLPPLP	DEG_APCC_DBOX_1	0.2778
p.H180N	SIDM01772	Mesothelioma	GDSC	RRGGLPPLP	DEG_APCC_DBOX_1	0.2778
p.G173E	ACH-001521	Skin Cancer	CCLE	RRGGLPPLP	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42768	Wiskott-Aldrich syndrome protein	DEG_APCC_DBOX_1	170:178	RRGGLPPLP	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons