DegronMD

Uniprot ID: Q9BWW7

Source protein: Transcriptional repressor scratch 1

Source gene: SCRT1

Class: DEG_SCF_FBW7_2

Location: 86:93

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 97.1

COIL: 0.9544

CONS_SCORE: 0.5013

DSS_SCORE: 0.5634

HELIX: 0.0305

FCONS_SCORE: 1.0783

RIG_SCORE: 0.6372

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A85V	DO233236	GACA	ICGC	PPPTPRPE	DEG_SCF_FBW7_2	0.3056
p.A85T	DO233823	GACA	ICGC	PPPTPRPE	DEG_SCF_FBW7_2	0.3056
p.A98V	DO49168	PACA	ICGC	PPPTPRPE	DEG_SCF_FBW7_2	0.1944
p.A80V	DO227802	COCA	ICGC	PPPTPRPE	DEG_SCF_FBW7_2	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWW7	Transcriptional repressor scratch 1	DEG_SCF_FBW7_2	86:93	PPPTPRPE	FBXW7	0.9953	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons