DegronMD

Uniprot ID: Q86TG7

Source protein: Retrotransposon-derived protein PEG10

Source gene: PEG10

Class: DEG_SIAH_1

Location: 253:261

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9984

ASA_SCORE: 104.3

COIL: 0.9419

CONS_SCORE: 0.7705

DSS_SCORE: 0.6011

HELIX: 0.0373

FCONS_SCORE: 1.0921

RIG_SCORE: 0.6548

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P270T	TCGA-66-2763	LUSC	TCGA	PPRALVLPH	DEG_SIAH_1	0.0833
p.P270T	DO27620	LUSC	ICGC	PPRALVLPH	DEG_SIAH_1	0.0833
p.R251H	TCGA-AX-A05S	UCEC	TCGA	PPRALVLPH	DEG_SIAH_1	0.2778
p.R251H	DO233088	GACA	ICGC	PPRALVLPH	DEG_SIAH_1	0.2778
p.R251H	DO50687	ORCA	ICGC	PPRALVLPH	DEG_SIAH_1	0.2778
p.R251H	DO43218	UCEC	ICGC	PPRALVLPH	DEG_SIAH_1	0.2778
p.D269N	TCGA-BS-A0U7	UCEC	TCGA	PPRALVLPH	DEG_SIAH_1	0.1111
p.D269N	DO41482	UCEC	ICGC	PPRALVLPH	DEG_SIAH_1	0.1111
p.R255Q	TCGA-D3-A8GD	SKCM	TCGA	PPRALVLPH	DEG_SIAH_1	0.6218
p.R255Q	DO50282	SKCM	ICGC	PPRALVLPH	DEG_SIAH_1	0.6218
p.R255Q	CW-2	large_intestine	COSMIC	PPRALVLPH	DEG_SIAH_1	0.6218
p.K249N	TCGA-DK-A2I1	BLCA	TCGA	PPRALVLPH	DEG_SIAH_1	0.3333
p.K249N	DO444	BLCA	ICGC	PPRALVLPH	DEG_SIAH_1	0.3333
p.A256V	DO233270	GACA	ICGC	PPRALVLPH	DEG_SIAH_1	0.6936
p.L250M	SIDM00789	Colorectal Carcinoma	GDSC	PPRALVLPH	DEG_SIAH_1	0.25
p.L250M	HCT-15	large_intestine	COSMIC	PPRALVLPH	DEG_SIAH_1	0.25
p.R245L	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PPRALVLPH	DEG_SIAH_1	0.1111
p.R245L	NCI-H441	lung	COSMIC	PPRALVLPH	DEG_SIAH_1	0.1111
p.R251C	SIDM01088	Endometrial Carcinoma	GDSC	PPRALVLPH	DEG_SIAH_1	0.2778
p.R251C	ACH-000795	Leukemia	CCLE	PPRALVLPH	DEG_SIAH_1	0.2778
p.R251C	RL95-2	endometrium	COSMIC	PPRALVLPH	DEG_SIAH_1	0.2778
p.R251C	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PPRALVLPH	DEG_SIAH_1	0.2778
p.N262S	SIDM00794	Other Solid Cancers	GDSC	PPRALVLPH	DEG_SIAH_1	0.3056
p.N262S	A388	skin	COSMIC	PPRALVLPH	DEG_SIAH_1	0.3056
p.P260S	ACH-000909	Endometrial/Uterine Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	0.6752
p.P260S	ACH-000946	Endometrial/Uterine Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	0.6752
p.A246G	ACH-000951	Lung Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	0.1389
p.A246G	NCI-H2342	lung	COSMIC	PPRALVLPH	DEG_SIAH_1	0.1389
p.H266L	ACH-002157	Lung Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	0.1944
p.H266L	LC-2-ad	lung	COSMIC	PPRALVLPH	DEG_SIAH_1	0.1944
p.S260L	NCI-SNU-1	stomach	COSMIC	PPRALVLPH	DEG_SIAH_1	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPRALVLPH

Degron related mutations and impact score

Drug responses associated with PEG10 mutations

All proteins holding degron of PPRALVLPH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TG7	Retrotransposon-derived protein PEG10	DEG_SIAH_1	253:261	PPRALVLPH	SIAH1,SIAH2,SIAH3	0.9984	More...