DegronMD - Q86TG7(PEG10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R62C	TCGA-18-3409	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1389
p.R62C	TCGA-BR-A4QL	STAD	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1389
p.R62C	DO26444	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1389
p.R62C	DO38723	STAD	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1389
p.E53G	TCGA-19-4065	GBM	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6087
p.E53G	DO11591	GBM	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6087
p.T51N	TCGA-60-2714	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.8166
p.T51N	DO26530	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.8166
p.D58N	TCGA-63-A5MU	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.25
p.D58N	DO219165	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.25
p.L44I	TCGA-64-5775	LUAD	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.2222
p.L44I	DO26025	LUAD	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.2222
p.P270T	TCGA-66-2763	LUSC	TCGA	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.0833
p.P270T	DO27620	LUSC	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.0833
p.T43I	TCGA-77-7139	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.T43I	DO27636	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.E49K	TCGA-AP-A0LM	UCEC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.591
p.E49K	DO50842	LIRI	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.591
p.E49K	DO43306	UCEC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.591
p.R251H	TCGA-AX-A05S	UCEC	TCGA	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.R251H	DO233088	GACA	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.R251H	DO50687	ORCA	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.R251H	DO43218	UCEC	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.D269N	TCGA-BS-A0U7	UCEC	TCGA	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1111
p.D269N	DO41482	UCEC	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1111
p.R255Q	TCGA-D3-A8GD	SKCM	TCGA	PPRALVLPH	DEG_SIAH_1	253:261	Mutation altering degron motif	0.6218
p.R255Q	DO50282	SKCM	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation altering degron motif	0.6218
p.R255Q	CW-2	large intestine	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation altering degron motif	0.6218
p.E60K	TCGA-DA-A1IC	SKCM	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.E60K	DO37430	SKCM	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.K249N	TCGA-DK-A2I1	BLCA	TCGA	PPRALVLPH	DEG_SIAH_1	253:261	Mutation substituting flanking lysine	0.3333
p.K249N	DO444	BLCA	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation substituting flanking lysine	0.3333
p.R45Q	TCGA-NH-A5IV	COAD	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.25
p.R45Q	DO49095	COAD	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.25
p.P50H	TCGA-QK-A8Z8	HNSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6583
p.P50H	DO52097	HNSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6583
p.E53D	TCGA-VS-A9U6	CESC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.5647
p.E53D	DO219728	CESC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.5647
p.A256V	DO233270	GACA	ICGC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation altering degron motif	0.6936
p.G63A	DO233823	GACA	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1111
p.P52S	DO231127	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6752
p.E49G	DO52686	MALY	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6087
p.L250M	SIDM00789	Colorectal Carcinoma	GDSC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.25
p.L250M	HCT-15	large intestine	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.25
p.R245L	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1111
p.R245L	NCI-H441	lung	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1111
p.R251C	SIDM01088	Endometrial Carcinoma	GDSC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.R251C	ACH-000795	Leukemia	CCLE	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.R251C	RL95-2	endometrium	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.R251C	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.2778
p.N262S	SIDM00794	Other Solid Cancers	GDSC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.3056
p.N262S	A388	skin	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.3056
p.E60Q	ACH-000893	Lung Cancer	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.E60Q	NCI-H1651	lung	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.P260S	ACH-000909	Endometrial/Uterine Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	253:261	Mutation altering degron motif	0.6752
p.P260S	ACH-000946	Endometrial/Uterine Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	253:261	Mutation altering degron motif	0.6752
p.D57N	ACH-000939	Sarcoma	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.2778
p.D57N	SK-UT-1	soft tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.2778
p.A246G	ACH-000951	Lung Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1389
p.A246G	NCI-H2342	lung	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1389
p.R62H	ACH-001669	Leukemia	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1389
p.R62H	ACH-002238	Leukemia	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1389
p.R62H	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1389
p.V48M	ACH-001738	Leukemia	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6097
p.V48M	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6097
p.H266L	ACH-002157	Lung Cancer	CCLE	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1944
p.H266L	LC-2-ad	lung	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.1944
p.R38Q	MCC13	skin	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation blocking phosphorylation signal	0.5
p.R38Q	MEL-JUSO	skin	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation blocking phosphorylation signal	0.5
p.S58L	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.25
p.S58L	HPAF-II	pancreas	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.25
p.S260L	NCI-SNU-1	stomach	COSMIC	PPRALVLPH	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7667

Kaplan plot for PEG10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PEG10

UniProt ID: Q86TG7

Entrez ID: 23089

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PEG10 in