DegronMD

Uniprot ID: Q86TG7

Source protein: Retrotransposon-derived protein PEG10

Source gene: PEG10

Class: DEG_SCF_FBW7_2

Location: 48:55

E3 ligase: FBXW7

DEGRON score: 0.8398

ASA_SCORE: 102.775

COIL: 0.899

CONS_SCORE: 0.5808

DSS_SCORE: 0.8508

HELIX: 0.0856

FCONS_SCORE: 0.8431

RIG_SCORE: 0.6554

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R62C	TCGA-18-3409	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.1389
p.R62C	TCGA-BR-A4QL	STAD	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.1389
p.R62C	DO26444	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.1389
p.R62C	DO38723	STAD	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.1389
p.E53G	TCGA-19-4065	GBM	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.6087
p.E53G	DO11591	GBM	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.6087
p.T51N	TCGA-60-2714	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.8166
p.T51N	DO26530	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.8166
p.D58N	TCGA-63-A5MU	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.25
p.D58N	DO219165	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.25
p.L44I	TCGA-64-5775	LUAD	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.2222
p.L44I	DO26025	LUAD	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.2222
p.T43I	TCGA-77-7139	LUSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.1944
p.T43I	DO27636	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.1944
p.E49K	TCGA-AP-A0LM	UCEC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.591
p.E49K	DO50842	LIRI	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.591
p.E49K	DO43306	UCEC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.591
p.E60K	TCGA-DA-A1IC	SKCM	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.1944
p.E60K	DO37430	SKCM	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.1944
p.R45Q	TCGA-NH-A5IV	COAD	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.25
p.R45Q	DO49095	COAD	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.25
p.P50H	TCGA-QK-A8Z8	HNSC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.6583
p.P50H	DO52097	HNSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.6583
p.E53D	TCGA-VS-A9U6	CESC	TCGA	VEPTPEDE	DEG_SCF_FBW7_2	0.5647
p.E53D	DO219728	CESC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.5647
p.G63A	DO233823	GACA	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.1111
p.P52S	DO231127	LUSC	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.6752
p.E49G	DO52686	MALY	ICGC	VEPTPEDE	DEG_SCF_FBW7_2	0.6087
p.E60Q	ACH-000893	Lung Cancer	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	0.1944
p.E60Q	NCI-H1651	lung	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.1944
p.D57N	ACH-000939	Sarcoma	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	0.2778
p.D57N	SK-UT-1	soft_tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.2778
p.R62H	ACH-001669	Leukemia	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	0.1389
p.R62H	ACH-002238	Leukemia	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	0.1389
p.R62H	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.1389
p.V48M	ACH-001738	Leukemia	CCLE	VEPTPEDE	DEG_SCF_FBW7_2	0.6097
p.V48M	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.6097
p.R38Q	MCC13	skin	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.5
p.R38Q	MEL-JUSO	skin	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.5
p.S58L	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.25
p.S58L	HPAF-II	pancreas	COSMIC	VEPTPEDE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VEPTPEDE

Degron related mutations and impact score

Drug responses associated with PEG10 mutations

All proteins holding degron of VEPTPEDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TG7	Retrotransposon-derived protein PEG10	DEG_SCF_FBW7_2	48:55	VEPTPEDE	FBXW7	0.8398	More...