DegronMD

Uniprot ID: Q15428

Source protein: Splicing factor 3A subunit 2

Source gene: SF3A2

Class: DEG_SIAH_1

Location: 367:375

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9565

ASA_SCORE: 70.9889

COIL: 0.9141

CONS_SCORE: 0.1701

DSS_SCORE: 0.7361

HELIX: 0.0249

FCONS_SCORE: 0.7969

RIG_SCORE: 0.5027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H358Q	DO38727	STAD	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.0833
p.V372G	DO229133	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.7532
p.V372G	DO229140	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.7532
p.V372G	DO229173	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.7532
p.V372G	DO229191	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.7532
p.V372G	DO229204	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.7532
p.V372G	DO229085	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.7532
p.A376P	DO229213	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.3056
p.H380Q	DO229240	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	0.1944
p.P374L	SIDM00006	Other Solid Cancers	GDSC	PPSAGVHPQ	DEG_SIAH_1	0.7582
p.P374L	ACH-001552	Skin Cancer	CCLE	PPSAGVHPQ	DEG_SIAH_1	0.7582
p.P368Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPSAGVHPQ	DEG_SIAH_1	0.7035
p.P374S	ACH-000952	Prostate Cancer	CCLE	PPSAGVHPQ	DEG_SIAH_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15428	Splicing factor 3A subunit 2	DEG_SIAH_1	367:375	PPSAGVHPQ	SIAH1,SIAH2,SIAH3	0.9565	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons