DegronMD - Q15428(SF3A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R29C	TCGA-AJ-A3EK	UCEC	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.719
p.R29C	DO41584	UCEC	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.719
p.S20Y	TCGA-DU-7294	LGG	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.S20Y	DO22333	LGG	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.N23S	TCGA-EE-A2GI	SKCM	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.N23S	DO37410	SKCM	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.S19F	TCGA-EE-A2GS	SKCM	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.S19F	TCGA-QB-AA9O	SKCM	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.S19F	DO37465	SKCM	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.S19F	DO51267	SKCM	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.D39Y	DO229015	LICA	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1944
p.H358Q	DO38727	STAD	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation rewiring degron network	0.0833
p.V372G	DO229133	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7532
p.V372G	DO229140	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7532
p.V372G	DO229173	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7532
p.V372G	DO229191	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7532
p.V372G	DO229204	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7532
p.V372G	DO229085	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7532
p.A376P	DO229213	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation rewiring degron network	0.3056
p.H380Q	DO229240	THCA	ICGC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation rewiring degron network	0.1944
p.R24C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2778
p.R24C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRERLRQLA	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2778
p.P374L	SIDM00006	Other Solid Cancers	GDSC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7582
p.P374L	ACH-001552	Skin Cancer	CCLE	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7582
p.P368Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.7035
p.P374S	ACH-000952	Prostate Cancer	CCLE	PPSAGVHPQ	DEG_SIAH_1	367:375	Mutation altering degron motif	0.6752

Kaplan plot for SF3A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SF3A2

UniProt ID: Q15428

Entrez ID: 8175

Protein name: Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SF3A2 in