DegronMD

Uniprot ID: Q15428

Source protein: Splicing factor 3A subunit 2

Source gene: SF3A2

Class: DEG_APCC_DBOX_1

Location: 26:34

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6411

ASA_SCORE: 75.4

COIL: 0.0407

CONS_SCORE: 0.6979

DSS_SCORE: 0.491

HELIX: 0.9571

FCONS_SCORE: 1.0672

RIG_SCORE: 0.7909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R29C	TCGA-AJ-A3EK	UCEC	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	0.719
p.R29C	DO41584	UCEC	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	0.719
p.S20Y	TCGA-DU-7294	LGG	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	0.1667
p.S20Y	DO22333	LGG	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	0.1667
p.N23S	TCGA-EE-A2GI	SKCM	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	0.25
p.N23S	DO37410	SKCM	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	0.25
p.S19F	TCGA-EE-A2GS	SKCM	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	0.1389
p.S19F	TCGA-QB-AA9O	SKCM	TCGA	RRERLRQLA	DEG_APCC_DBOX_1	0.1389
p.S19F	DO37465	SKCM	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	0.1389
p.S19F	DO51267	SKCM	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	0.1389
p.D39Y	DO229015	LICA	ICGC	RRERLRQLA	DEG_APCC_DBOX_1	0.1944
p.R24C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RRERLRQLA	DEG_APCC_DBOX_1	0.2778
p.R24C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRERLRQLA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15428	Splicing factor 3A subunit 2	DEG_APCC_DBOX_1	26:34	RRERLRQLA	APC,CDC20,FZR1	0.6411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons