DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPSTPPWE
Uniprot ID:
Q8NA69
Source protein:
Testis-expressed protein 45
Source gene:
TEX45
Class:
DEG_SCF_FBW7_2
Location:
88:95
E3 ligase:
FBXW7
DEGRON score:
0.6066
ASA_SCORE:
83.6125
COIL:
0.7528
CONS_SCORE:
0.3007
DSS_SCORE:
0.598
HELIX:
0.2381
FCONS_SCORE:
0.7482
RIG_SCORE:
0.6529
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TEX45 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPSTPPWE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NA69
Testis-expressed protein 45
DEG_SCF_FBW7_2
88:95
PPSTPPWE
FBXW7
0.6066
More...