DegronMD

Uniprot ID: Q8NHG7

Source protein: Small VCP/p97-interacting protein

Source gene: SVIP

Class: DEG_SCF_FBW7_2

Location: 13:19

E3 ligase: FBXW7

DEGRON score: 0.5655

ASA_SCORE: 94.1429

COIL: 0.6999

CONS_SCORE: 0.8391

DSS_SCORE: 0.5838

HELIX: 0.2889

FCONS_SCORE: 0.8744

RIG_SCORE: 0.6642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A29S	TCGA-85-8276	LUSC	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.0556
p.A29S	DO26436	LUSC	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.0556
p.A28D	TCGA-A5-A1OF	UCEC	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.0833
p.A28D	DO42568	UCEC	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.0833
p.R22I	TCGA-AP-A051	UCEC	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.25
p.R22I	DO42673	UCEC	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.25
p.P6H	TCGA-D3-A1QA	SKCM	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.1389
p.P6H	DO47469	SKCM	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.1389
p.P14H	TCGA-DD-AAVV	LIHC	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.6583
p.P14H	DO223912	LIHC	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.6583
p.G9W	TCGA-EM-A2CL	THCA	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.2222
p.G9W	DO40640	THCA	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.2222
p.K21N	TCGA-FZ-5919	PAAD	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.2778
p.K21N	DO218972	PAAD	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.2778
p.A26V	TCGA-XK-AAIW	PRAD	TCGA	PPTPDLE	DEG_SCF_FBW7_2	0.1389
p.A26V	DO51407	PRAD	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.1389
p.A29E	DO230463	PACA	ICGC	PPTPDLE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHG7	Small VCP/p97-interacting protein	DEG_SCF_FBW7_2	13:19	PPTPDLE	FBXW7	0.5655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons