DegronMD

Uniprot ID: Q6PGN9

Source protein: Proline/serine-rich coiled-coil protein 1

Source gene: PSRC1

Class: DEG_SCF_FBW7_1

Location: 243:249

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 100.8143

COIL: 0.9343

CONS_SCORE: 0.7787

DSS_SCORE: 0.7139

HELIX: 0.0181

FCONS_SCORE: 1.5633

RIG_SCORE: 0.6384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S258N	TCGA-AX-A06F	UCEC	TCGA	PPTPIRS	DEG_SCF_FBW7_1	0.0833
p.S245R	TCGA-KB-A6F7	STAD	TCGA	PPTPIRS	DEG_SCF_FBW7_1	0.7427
p.T245N	DO228952	LICA	ICGC	PPTPIRS	DEG_SCF_FBW7_1	0.8166
p.A252D	DO229037	LICA	ICGC	PPTPIRS	DEG_SCF_FBW7_1	0.25
p.V250I	DO36305	PRAD	ICGC	PPTPIRS	DEG_SCF_FBW7_1	0.3056
p.P246S	DO220036	SARC	ICGC	PPTPIRS	DEG_SCF_FBW7_1	0.6752
p.I247M	DO41349	UCEC	ICGC	PPTPIRS	DEG_SCF_FBW7_1	0.6507
p.I253S	SIDM00290	Gastric Carcinoma	GDSC	PPTPIRS	DEG_SCF_FBW7_1	0.2222
p.I253S	ACH-000847	Gastric Cancer	CCLE	PPTPIRS	DEG_SCF_FBW7_1	0.2222
p.I253S	HGC-27	stomach	COSMIC	PPTPIRS	DEG_SCF_FBW7_1	0.2222
p.S249T	NCC010	kidney	COSMIC	PPTPIRS	DEG_SCF_FBW7_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGN9	Proline/serine-rich coiled-coil protein 1	DEG_SCF_FBW7_1	243:249	PPTPIRS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons