DegronMD - Q6PGN9(PSRC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S65C	TCGA-AA-3663	COAD	TCGA	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7541
p.S65C	DO9346	COAD	ICGC	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7541
p.R114W	TCGA-AA-3715	COAD	TCGA	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0556
p.R114W	DO8018	COAD	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0556
p.S258N	TCGA-AX-A06F	UCEC	TCGA	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation rewiring degron network	0.0833
p.T130I	TCGA-BR-4368	STAD	TCGA	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5966
p.T130I	DO38715	STAD	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5966
p.P141S	TCGA-EE-A29E	SKCM	TCGA	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.P141S	DO37831	SKCM	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.S245R	TCGA-KB-A6F7	STAD	TCGA	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation altering degron motif	0.7427
p.P352H	DO10582	COAD	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111
p.R136W	DO233270	GACA	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.R326W	DO233823	GACA	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0556
p.R326W	DO42472	UCEC	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0556
p.R326W	ACH-000995	Leukemia	CCLE	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0556
p.R326W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0556
p.V332I	DO13653	GBM	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.2222
p.T245N	DO228952	LICA	ICGC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation altering degron motif	0.8166
p.L127M	DO228971	LICA	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5999
p.T346N	DO229036	LICA	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation blocking phosphorylation signal	0.7222
p.A252D	DO229037	LICA	ICGC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation rewiring degron network	0.25
p.V250I	DO36305	PRAD	ICGC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation rewiring degron network	0.3056
p.P246S	DO220036	SARC	ICGC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation altering degron motif	0.6752
p.P333S	DO43202	UCEC	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.25
p.I247M	DO41349	UCEC	ICGC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation altering degron motif	0.6507
p.V62A	SIDM00683	Prostate Carcinoma	GDSC	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.5825
p.V62A	ACH-000977	lymph node	CCLE	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.5825
p.I253S	SIDM00290	Gastric Carcinoma	GDSC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation rewiring degron network	0.2222
p.I253S	ACH-000847	Gastric Cancer	CCLE	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation rewiring degron network	0.2222
p.I253S	HGC-27	stomach	COSMIC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation rewiring degron network	0.2222
p.V62L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.5654
p.V62L	SIDM00808	Burkitt's Lymphoma	GDSC	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.5654
p.V62L	SIDM00785	Acute Myeloid Leukemia	GDSC	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.5654
p.V62L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.5654
p.V62L	SIDM01254	Burkitt's Lymphoma	GDSC	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.5654
p.E115Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.E115Q	ACH-001737	Leukemia	CCLE	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.E115Q	ACH-002222	Leukemia	CCLE	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.E115Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VRDLLPTVN	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.E76D	ACH-000922	Leukemia	CCLE	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1667
p.E75A	ACH-001275	Sarcoma	CCLE	VRLSLGPLS	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1944
p.S249T	NCC010	kidney	COSMIC	PPTPIRS	DEG_SCF_FBW7_1	243:249	Mutation altering degron motif	0.6005
p.P353L	OC-314	ovary	COSMIC	QRLNLPVMG	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.0833

Kaplan plot for PSRC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSRC1

UniProt ID: Q6PGN9

Entrez ID: 84722

Protein name: Proline/serine-rich coiled-coil protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSRC1 in