DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRLSLGPLS
Uniprot ID:
Q6PGN9
Source protein:
Proline/serine-rich coiled-coil protein 1
Source gene:
PSRC1
Class:
DEG_APCC_DBOX_1
Location:
62:70
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9967
ASA_SCORE:
66.0889
COIL:
0.8324
CONS_SCORE:
0.9439
DSS_SCORE:
0.5019
HELIX:
0.0226
FCONS_SCORE:
1.0144
RIG_SCORE:
0.6674
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S65C
TCGA-AA-3663
COAD
TCGA
VRLSLGPLS
DEG_APCC_DBOX_1
0.7541
p.S65C
DO9346
COAD
ICGC
VRLSLGPLS
DEG_APCC_DBOX_1
0.7541
p.V62A
SIDM00683
Prostate Carcinoma
GDSC
VRLSLGPLS
DEG_APCC_DBOX_1
0.5825
p.V62A
ACH-000977
lymph_node
CCLE
VRLSLGPLS
DEG_APCC_DBOX_1
0.5825
p.V62L
SIDM01072
Squamous Cell Lung Carcinoma
GDSC
VRLSLGPLS
DEG_APCC_DBOX_1
0.5654
p.V62L
SIDM00808
Burkitt's Lymphoma
GDSC
VRLSLGPLS
DEG_APCC_DBOX_1
0.5654
p.V62L
SIDM00785
Acute Myeloid Leukemia
GDSC
VRLSLGPLS
DEG_APCC_DBOX_1
0.5654
p.V62L
SIDM01710
Squamous Cell Lung Carcinoma
GDSC
VRLSLGPLS
DEG_APCC_DBOX_1
0.5654
p.V62L
SIDM01254
Burkitt's Lymphoma
GDSC
VRLSLGPLS
DEG_APCC_DBOX_1
0.5654
p.E76D
ACH-000922
Leukemia
CCLE
VRLSLGPLS
DEG_APCC_DBOX_1
0.1667
p.E75A
ACH-001275
Sarcoma
CCLE
VRLSLGPLS
DEG_APCC_DBOX_1
0.1944
Drug responses associated with PSRC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRLSLGPLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6PGN9
Proline/serine-rich coiled-coil protein 1
DEG_APCC_DBOX_1
62:70
VRLSLGPLS
APC,CDC20,FZR1
0.9967
More...