DegronMD

Uniprot ID: Q6PGN9

Source protein: Proline/serine-rich coiled-coil protein 1

Source gene: PSRC1

Class: DEG_APCC_DBOX_1

Location: 124:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 76.6556

COIL: 0.7849

CONS_SCORE: 0.9591

DSS_SCORE: 0.5379

HELIX: 0.1628

FCONS_SCORE: 1.0703

RIG_SCORE: 0.7399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R114W	TCGA-AA-3715	COAD	TCGA	VRDLLPTVN	DEG_APCC_DBOX_1	0.0556
p.R114W	DO8018	COAD	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	0.0556
p.T130I	TCGA-BR-4368	STAD	TCGA	VRDLLPTVN	DEG_APCC_DBOX_1	0.5966
p.T130I	DO38715	STAD	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	0.5966
p.P141S	TCGA-EE-A29E	SKCM	TCGA	VRDLLPTVN	DEG_APCC_DBOX_1	0.0833
p.P141S	DO37831	SKCM	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	0.0833
p.R136W	DO233270	GACA	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	0.2222
p.L127M	DO228971	LICA	ICGC	VRDLLPTVN	DEG_APCC_DBOX_1	0.5999
p.E115Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VRDLLPTVN	DEG_APCC_DBOX_1	0.0833
p.E115Q	ACH-001737	Leukemia	CCLE	VRDLLPTVN	DEG_APCC_DBOX_1	0.0833
p.E115Q	ACH-002222	Leukemia	CCLE	VRDLLPTVN	DEG_APCC_DBOX_1	0.0833
p.E115Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRDLLPTVN	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGN9	Proline/serine-rich coiled-coil protein 1	DEG_APCC_DBOX_1	124:132	VRDLLPTVN	APC,CDC20,FZR1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons