DegronMD

Uniprot ID: Q6PGN9

Source protein: Proline/serine-rich coiled-coil protein 1

Source gene: PSRC1

Class: DEG_APCC_DBOX_1

Location: 336:344

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9769

ASA_SCORE: 101.6667

COIL: 0.875

CONS_SCORE: 0.7387

DSS_SCORE: 0.6191

HELIX: 0.0841

FCONS_SCORE: 1.1699

RIG_SCORE: 0.719

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T346N	DO229036	LICA	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	0.7222
p.P333S	DO43202	UCEC	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	0.25
p.V332I	DO13653	GBM	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	0.2222
p.P352H	DO10582	COAD	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	0.1111
p.P353L	OC-314	ovary	COSMIC	QRLNLPVMG	DEG_APCC_DBOX_1	0.0833
p.R326W	DO233823	GACA	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	0.0556
p.R326W	DO42472	UCEC	ICGC	QRLNLPVMG	DEG_APCC_DBOX_1	0.0556
p.R326W	ACH-000995	Leukemia	CCLE	QRLNLPVMG	DEG_APCC_DBOX_1	0.0556
p.R326W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	QRLNLPVMG	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGN9	Proline/serine-rich coiled-coil protein 1	DEG_APCC_DBOX_1	336:344	QRLNLPVMG	APC,CDC20,FZR1	0.9769	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons