DegronMD

Uniprot ID: Q9HBM0

Source protein: Vezatin

Source gene: VEZT

Class: DEG_SCF_FBW7_1

Location: 711:717

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 83.4857

COIL: 0.9283

CONS_SCORE: 0.3575

DSS_SCORE: 0.7214

HELIX: 0.0504

FCONS_SCORE: 1.1303

RIG_SCORE: 0.6492

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A702T	TCGA-A5-A0G1	UCEC	TCGA	PPTPRDS	DEG_SCF_FBW7_1	0.0833
p.A702T	DO42472	UCEC	ICGC	PPTPRDS	DEG_SCF_FBW7_1	0.0833
p.L726M	TCGA-B5-A3FA	UCEC	TCGA	PPTPRDS	DEG_SCF_FBW7_1	0.0833
p.L726M	DO52402	UCEC	ICGC	PPTPRDS	DEG_SCF_FBW7_1	0.0833
p.P711S	TCGA-BP-4995	KIRC	TCGA	PPTPRDS	DEG_SCF_FBW7_1	0.6752
p.P711S	DO16370	KIRC	ICGC	PPTPRDS	DEG_SCF_FBW7_1	0.6752
p.T708A	TCGA-BR-4368	STAD	TCGA	PPTPRDS	DEG_SCF_FBW7_1	0.25
p.T708A	DO38715	STAD	ICGC	PPTPRDS	DEG_SCF_FBW7_1	0.25
p.P720S	TCGA-FW-A3R5	SKCM	TCGA	PPTPRDS	DEG_SCF_FBW7_1	0.25
p.P720S	DO37406	SKCM	ICGC	PPTPRDS	DEG_SCF_FBW7_1	0.25
p.I722N	SIDM01111	Ewing's Sarcoma	GDSC	PPTPRDS	DEG_SCF_FBW7_1	0.1944
p.I722N	ACH-000087	Bone Cancer	CCLE	PPTPRDS	DEG_SCF_FBW7_1	0.1944
p.I722N	SK-ES-1	bone	COSMIC	PPTPRDS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBM0	Vezatin	DEG_SCF_FBW7_1	711:717	PPTPRDS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons