DegronMD

Uniprot ID: O75553

Source protein: Disabled homolog 1

Source gene: DAB1

Class: DEG_SIAH_1

Location: 360:368

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9855

ASA_SCORE: 59.8889

COIL: 0.807

CONS_SCORE: 0.4191

DSS_SCORE: 0.3768

HELIX: 0.1069

FCONS_SCORE: 0.9216

RIG_SCORE: 0.7366

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q360K	TCGA-25-2404	OV	TCGA	PPVAQVMPG	DEG_SIAH_1	0.6944
p.Q360K	TCGA-78-7536	LUAD	TCGA	PPVAQVMPG	DEG_SIAH_1	0.6944
p.P355S	TCGA-60-2710	LUSC	TCGA	PPVAQVMPG	DEG_SIAH_1	0.1944
p.P355S	TCGA-D3-A2J8	SKCM	TCGA	PPVAQVMPG	DEG_SIAH_1	0.1944
p.P368T	TCGA-78-7535	LUAD	TCGA	PPVAQVMPG	DEG_SIAH_1	0.7031
p.T369I	TCGA-AP-A1DK	UCEC	TCGA	PPVAQVMPG	DEG_SIAH_1	0.3056
p.L375S	TCGA-B5-A1MW	UCEC	TCGA	PPVAQVMPG	DEG_SIAH_1	0.1389
p.V372A	TCGA-BG-A222	UCEC	TCGA	PPVAQVMPG	DEG_SIAH_1	0.2222
p.Q351H	TCGA-DA-A3F3	SKCM	TCGA	PPVAQVMPG	DEG_SIAH_1	0.0833
p.P362L	TCGA-FR-A3YO	SKCM	TCGA	PPVAQVMPG	DEG_SIAH_1	0.7582
p.P355A	TCGA-MN-A4N5	LUAD	TCGA	PPVAQVMPG	DEG_SIAH_1	0.1944
p.D375Y	DO486	BLCA	ICGC	PPVAQVMPG	DEG_SIAH_1	0.1389
p.C352S	DO486	BLCA	ICGC	PPVAQVMPG	DEG_SIAH_1	0.1111
p.D371N	DO219594	BRCA	ICGC	PPVAQVMPG	DEG_SIAH_1	0.25
p.E355K	DO44438	HNSC	ICGC	PPVAQVMPG	DEG_SIAH_1	0.1944
p.F376Y	DO48701	LIRI	ICGC	PPVAQVMPG	DEG_SIAH_1	0.1111
p.I378N	DO48701	LIRI	ICGC	PPVAQVMPG	DEG_SIAH_1	0.0556
p.Q368H	DO23624	LUAD	ICGC	PPVAQVMPG	DEG_SIAH_1	0.7582
p.L350F	DO48574	PAEN	ICGC	PPVAQVMPG	DEG_SIAH_1	0.0556
p.V366L	DO46844	RECA	ICGC	PPVAQVMPG	DEG_SIAH_1	0.6765
p.D369N	DO218900	SKCA	ICGC	PPVAQVMPG	DEG_SIAH_1	0.3056
p.D377Y	DO38075	SKCM	ICGC	PPVAQVMPG	DEG_SIAH_1	0.0833
p.S358F	DO51254	SKCM	ICGC	PPVAQVMPG	DEG_SIAH_1	0.2778
p.Q352H	SIDM01036	Plasma Cell Myeloma	GDSC	PPVAQVMPG	DEG_SIAH_1	0.1111
p.Q352H	ACH-000653	Myeloma	CCLE	PPVAQVMPG	DEG_SIAH_1	0.1111
p.Q352H	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.1111
p.P376A	SIDM00845	Burkitt's Lymphoma	GDSC	PPVAQVMPG	DEG_SIAH_1	0.1111
p.P376A	ACH-000786	Lymphoma	CCLE	PPVAQVMPG	DEG_SIAH_1	0.1111
p.A378T	SIDM00936	Bladder Carcinoma	GDSC	PPVAQVMPG	DEG_SIAH_1	0.0556
p.A378T	ACH-000142	Bladder Cancer	CCLE	PPVAQVMPG	DEG_SIAH_1	0.0556
p.A378T	CAL-29	urinary_tract	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.0556
p.P362Q	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PPVAQVMPG	DEG_SIAH_1	0.7035
p.P362Q	ACH-000747	Lung Cancer	CCLE	PPVAQVMPG	DEG_SIAH_1	0.7035
p.P362Q	NCI-H1703	lung	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.7035
p.A378V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPVAQVMPG	DEG_SIAH_1	0.0556
p.A378V	ACH-001127	Leukemia	CCLE	PPVAQVMPG	DEG_SIAH_1	0.0556
p.A378V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.0556
p.P368A	SIDM01435	Hepatocellular Carcinoma	GDSC	PPVAQVMPG	DEG_SIAH_1	0.7503
p.P368A	ACH-000686	Liver Cancer	CCLE	PPVAQVMPG	DEG_SIAH_1	0.7503
p.A376V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.1111
p.A376T	CAL-29	urinary_tract	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.1111
p.Q350H	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.0556
p.I372V	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.2222
p.A363T	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.7139
p.Q370R	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.2778
p.P360Q	NCI-H1703	lung	COSMIC	PPVAQVMPG	DEG_SIAH_1	0.5924

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVAQVMPG

Degron related mutations and impact score

Drug responses associated with DAB1 mutations

All proteins holding degron of PPVAQVMPG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75553	Disabled homolog 1	DEG_SIAH_1	360:368	PPVAQVMPG	SIAH1,SIAH2,SIAH3	0.9855	More...