DegronMD

Uniprot ID: Q8IZY2

Source protein: Phospholipid-transporting ATPase ABCA7

Source gene: ABCA7

Class: DEG_SCF_FBW7_2

Location: 83:90

E3 ligase: FBXW7

DEGRON score: 0.5829

ASA_SCORE: 71.0875

COIL: 0.8823

CONS_SCORE: 0.233

DSS_SCORE: 0.3609

HELIX: 0.0356

FCONS_SCORE: 1.0107

RIG_SCORE: 0.7573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T80A	TCGA-69-7979	LUAD	TCGA	PQLTPGEE	DEG_SCF_FBW7_2	0.25
p.T80A	DO23874	LUAD	ICGC	PQLTPGEE	DEG_SCF_FBW7_2	0.25
p.E89D	TCGA-A5-A1OF	UCEC	TCGA	PQLTPGEE	DEG_SCF_FBW7_2	0.5647
p.E89D	DO42568	UCEC	ICGC	PQLTPGEE	DEG_SCF_FBW7_2	0.5647
p.E89D	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PQLTPGEE	DEG_SCF_FBW7_2	0.5647
p.E89D	ACH-002222	Leukemia	CCLE	PQLTPGEE	DEG_SCF_FBW7_2	0.5647
p.E89D	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PQLTPGEE	DEG_SCF_FBW7_2	0.5647
p.E90K	TCGA-D9-A6EC	SKCM	TCGA	PQLTPGEE	DEG_SCF_FBW7_2	0.7022
p.E90K	DO50291	SKCM	ICGC	PQLTPGEE	DEG_SCF_FBW7_2	0.7022
p.L73F	DO222798	COCA	ICGC	PQLTPGEE	DEG_SCF_FBW7_2	0.0556
p.L85M	SIDM00203	Ewing's Sarcoma	GDSC	PQLTPGEE	DEG_SCF_FBW7_2	0.5999
p.L85M	SIDM01387	Small Cell Lung Carcinoma	GDSC	PQLTPGEE	DEG_SCF_FBW7_2	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZY2	Phospholipid-transporting ATPase ABCA7	DEG_SCF_FBW7_2	83:90	PQLTPGEE	FBXW7	0.5829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons