DegronMD

Uniprot ID: Q8TDN2

Source protein: Potassium voltage-gated channel subfamily V member 2

Source gene: KCNV2

Class: DEG_SCF_FBW7_2

Location: 537:544

E3 ligase: FBXW7

DEGRON score: 0.8393

ASA_SCORE: 127.675

COIL: 0.9338

CONS_SCORE: 0.4525

DSS_SCORE: 0.7968

HELIX: 0.0449

FCONS_SCORE: 1.0772

RIG_SCORE: 0.6893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E544D	TCGA-AA-3510	COAD	TCGA	PQLTPRQE	DEG_SCF_FBW7_2	0.6758
p.E544D	DO7783	COAD	ICGC	PQLTPRQE	DEG_SCF_FBW7_2	0.6758
p.E544D	SIDM00193	Colorectal Carcinoma	GDSC	PQLTPRQE	DEG_SCF_FBW7_2	0.6758
p.E544D	SIDM01588	Endometrial Carcinoma	GDSC	PQLTPRQE	DEG_SCF_FBW7_2	0.6758
p.E544D	ACH-000991	Colon/Colorectal Cancer	CCLE	PQLTPRQE	DEG_SCF_FBW7_2	0.6758
p.E544D	ACH-000993	Endometrial/Uterine Cancer	CCLE	PQLTPRQE	DEG_SCF_FBW7_2	0.6758
p.E544D	SNU-81	large_intestine	COSMIC	PQLTPRQE	DEG_SCF_FBW7_2	0.6758
p.Q538H	DO229045	LICA	ICGC	PQLTPRQE	DEG_SCF_FBW7_2	0.647
p.Q538H	DO232761	PBCA	ICGC	PQLTPRQE	DEG_SCF_FBW7_2	0.647
p.N536S	SIDM00183	Small Cell Lung Carcinoma	GDSC	PQLTPRQE	DEG_SCF_FBW7_2	0.3056
p.N536S	SIDM01648	Non-Cancerous	GDSC	PQLTPRQE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDN2	Potassium voltage-gated channel subfamily V member 2	DEG_SCF_FBW7_2	537:544	PQLTPRQE	FBXW7	0.8393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons