DegronMD

Uniprot ID: Q9UKF5

Source protein: Disintegrin and metalloproteinase domain-containing protein 29

Source gene: ADAM29

Class: DEG_SCF_FBW7_1

Location: 788:795

E3 ligase: FBXW7

DEGRON score: 0.8263

ASA_SCORE: 97.6625

COIL: 0.9629

CONS_SCORE: 0.4847

DSS_SCORE: 0.905

HELIX: 0.0163

FCONS_SCORE: 1.0178

RIG_SCORE: 0.4897

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q803K	TCGA-29-1702	OV	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.1111
p.Q803K	DO29528	OV	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.1111
p.P792R	TCGA-37-3783	LUSC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.7512
p.P792R	DO26734	LUSC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.7512
p.L790S	TCGA-AA-A02Y	COAD	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.6556
p.L790S	DO7858	COAD	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.6556
p.L790F	TCGA-B5-A0JY	UCEC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.587
p.L790F	DO43041	UCEC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.587
p.Q803H	TCGA-D8-A1JN	BRCA	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.1111
p.Q803H	DO4311	BRCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.1111
p.P780S	TCGA-EB-A41A	SKCM	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.1111
p.P780S	DO220902	MELA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.1111
p.P780S	DO37429	SKCM	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.1111
p.S793Y	TCGA-EO-A22X	UCEC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.6009
p.S793Y	DO43907	UCEC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.6009
p.Q794H	TCGA-IB-7651	PAAD	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.647
p.Q794H	DO46657	PAAD	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.647
p.P792T	TCGA-UB-A7MB	LIHC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.7031
p.P792T	DO52318	LIHC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.7031
p.S802F	TCGA-YF-AA3L	BLCA	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	0.1389
p.S802F	DO51951	BLCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.1389
p.R804S	DO224668	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R804S	DO222733	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R804S	DOV13	ovary	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R804S	NCI-H28	pleura	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R804S	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R804S	NCI-H810	lung	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R804S	CAL-33	upper_aerodigestive_tract	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R804S	NCI-SNU-16	stomach	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.0833
p.T800I	DO224668	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.1944
p.T800I	DO227841	PBCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.1944
p.Q805H	DO224668	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.0556
p.Q805H	DO227841	PBCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.0556
p.Q805H	DO233027	PEME	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.0556
p.P798S	DO220903	MELA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	0.25
p.Q796P	SIDM00994	T-Lymphoblastic Leukemia	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	0.3056
p.Q796P	ACH-000105	Leukemia	CCLE	PQLTPSQS	DEG_SCF_FBW7_1	0.3056
p.Q796P	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.3056
p.M782I	SIDM00582	Pancreatic Carcinoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	0.1667
p.M782I	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	0.1667
p.M782I	SIDM01526	Mesothelioma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	0.1667
p.M782I	TE-9	oesophagus	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.1667
p.M782I	KP-2	pancreas	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.1667
p.P783A	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	0.1944
p.P783A	ACH-000226	Lymphoma	CCLE	PQLTPSQS	DEG_SCF_FBW7_1	0.1944
p.P783A	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.1944
p.Q794R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	0.6218
p.Q794R	ACH-002272	Lymphoma	CCLE	PQLTPSQS	DEG_SCF_FBW7_1	0.6218
p.Q794R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	0.6218

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQLTPSQS

Degron related mutations and impact score

Drug responses associated with ADAM29 mutations

All proteins holding degron of PQLTPSQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKF5	Disintegrin and metalloproteinase domain-containing protein 29	DEG_SCF_FBW7_1	788:795	PQLTPSQS	FBXW7	0.8263	More...