DegronMD - Q9UKF5(ADAM29)

FUNCTION: May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

GO - Biological processes (BP): male gonad development [GO:0008584]; spermatogenesis [GO:0007283]

GO - Molecular function (MF): metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]

GO - Cellular component (CC): external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P747L	TCGA-BF-A1Q0	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7582
p.P747L	DO47374	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7582
p.P765L	DO220898	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.7582
p.P792R	TCGA-37-3783	LUSC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7512
p.P792R	DO26734	LUSC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7512
p.S768R	DO228900	LICA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.7427
p.S750R	DO47171	RECA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7427
p.T746M	TCGA-33-4589	LUSC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	DO6370	CLLE	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	DO48292	ESCA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	DO26623	LUSC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	ACH-000765	Skin Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	ACH-002014	Eye Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.P792T	TCGA-UB-A7MB	LIHC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7031
p.P792T	DO52318	LIHC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7031
p.P743S	TCGA-FS-A4F5	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6752
p.P743S	DO37881	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6752
p.Q749L	TCGA-E6-A1LX	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6654
p.Q749L	DO41020	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6654
p.P744H	TCGA-BK-A6W3	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6583

Showing 1 to 20 of 113 entries

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Kaplan plot for ADAM29 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAM29

UniProt ID: Q9UKF5

Entrez ID: 11086

Protein name: Disintegrin and metalloproteinase domain-containing protein 29 (ADAM 29) (Cancer/testis antigen 73) (CT73)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAM29 in