DegronMD - Q9UKF5(ADAM29)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V763L	TCGA-19-5955	GBM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.5654
p.V763L	DO12208	GBM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.5654
p.Q803K	TCGA-29-1702	OV	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.Q803K	DO29528	OV	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.T746M	TCGA-33-4589	LUSC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	DO6370	CLLE	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	DO48292	ESCA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	DO26623	LUSC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	ACH-000765	Skin Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.T746M	ACH-002014	Eye Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7423
p.P792R	TCGA-37-3783	LUSC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7512
p.P792R	DO26734	LUSC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7512
p.Q742L	TCGA-92-8063	LUSC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.3056
p.Q742L	DO26941	LUSC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.3056
p.L790S	TCGA-AA-A02Y	COAD	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6556
p.L790S	DO7858	COAD	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6556
p.Q749H	TCGA-AP-A051	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.647
p.Q749H	DO42673	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.647
p.P762L	TCGA-AX-A06F	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.6471
p.P762L	DO41752	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.6471
p.R771W	TCGA-AZ-6598	COAD	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.25
p.R771W	DO10276	COAD	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.25
p.L790F	TCGA-B5-A0JY	UCEC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.587
p.L790F	DO43041	UCEC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.587
p.P747L	TCGA-BF-A1Q0	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7582
p.P747L	DO47374	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7582
p.P744H	TCGA-BK-A6W3	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6583
p.P744H	DO50076	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6583
p.S757F	TCGA-D3-A3MV	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.1389
p.S757F	TCGA-D3-A3MV	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2222
p.S757F	DO37727	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.1389
p.S757F	DO37727	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2222
p.Q803H	TCGA-D8-A1JN	BRCA	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.Q803H	DO4311	BRCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.Q749L	TCGA-E6-A1LX	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6654
p.Q749L	DO41020	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6654
p.P780S	TCGA-EB-A41A	SKCM	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.P780S	DO220902	MELA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.P780S	DO37429	SKCM	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1111
p.P762S	TCGA-EE-A2GB	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.5641
p.P762S	DO222683	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.5641
p.P762S	DO37417	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.5641
p.S793Y	TCGA-EO-A22X	UCEC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6009
p.S793Y	DO43907	UCEC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6009
p.P734T	TCGA-FC-A8O0	PRAD	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.0833
p.P734T	DO49765	PRAD	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.0833
p.P743S	TCGA-FS-A4F5	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6752
p.P743S	DO37881	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.6752
p.S739F	TCGA-GF-A6C9	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2222
p.S739F	DO51254	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2222
p.Q794H	TCGA-IB-7651	PAAD	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.647
p.Q794H	DO46657	PAAD	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.647
p.P792T	TCGA-UB-A7MB	LIHC	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7031
p.P792T	DO52318	LIHC	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7031
p.S802F	TCGA-YF-AA3L	BLCA	TCGA	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1389
p.S802F	DO51951	BLCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1389
p.P762A	TCGA-ZF-A9RL	BLCA	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.6392
p.P762A	DO219078	BLCA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.6392
p.R804S	DO224668	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R804S	DO222733	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R804S	DOV13	ovary	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R804S	NCI-H28	pleura	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R804S	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R804S	NCI-H810	lung	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R804S	CAL-33	upper aerodigestive tract	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.R804S	NCI-SNU-16	stomach	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.T800I	DO224668	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.T800I	DO227841	PBCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.Q805H	DO224668	COCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0556
p.Q805H	DO227841	PBCA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0556
p.Q805H	DO233027	PEME	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0556
p.M773T	DO222869	COCA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1944
p.M773T	DO48746	LIRI	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1944
p.M773T	DO48703	LIRI	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1944
p.P770H	DO233903	GACA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2778
p.S768R	DO228900	LICA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.7427
p.V754M	DO220877	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2222
p.V754M	DO220877	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1389
p.P765L	DO220898	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.7582
p.P798S	DO220903	MELA	ICGC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.Q733E	DO34608	PACA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.0556
p.S750R	DO47171	RECA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation altering degron motif	0.7427
p.S759R	SIDM01276	Colorectal Carcinoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.0833
p.S759R	SIDM01276	Colorectal Carcinoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2778
p.Q796P	SIDM00994	T-Lymphoblastic Leukemia	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.3056
p.Q796P	ACH-000105	Leukemia	CCLE	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.3056
p.Q796P	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.3056
p.M782I	SIDM00582	Pancreatic Carcinoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.M782I	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.M782I	SIDM01526	Mesothelioma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.M782I	TE-9	oesophagus	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.M782I	KP-2	pancreas	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1667
p.P783A	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.P783A	ACH-000226	Lymphoma	CCLE	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.P783A	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.Q794R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6218
p.Q794R	ACH-002272	Lymphoma	CCLE	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6218
p.Q794R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PQLTPSQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6218
p.P752S	SIDM01060	Melanoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.P752S	SIDM01060	Melanoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.0833
p.P752S	ACH-000882	Skin Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.P752S	ACH-000882	Skin Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.0833
p.P752S	IGR-1	skin	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.P752S	IGR-1	skin	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.0833
p.P774H	SIDM00878	Breast Carcinoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1667
p.P774H	ACH-000930	Breast Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1667
p.P774H	HCC1569	breast	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1667
p.P762H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.6583
p.P762H	MFE-319	endometrium	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.6583
p.P752L	ACH-002396	Bone Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.P752L	ACH-002396	Bone Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.0833
p.P752L	Sarc9371	bone	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	743:750	Mutation rewiring degron network	0.2778
p.P752L	Sarc9371	bone	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAM29

UniProt ID: Q9UKF5

Entrez ID: 11086

Protein name: Disintegrin and metalloproteinase domain-containing protein 29 (ADAM 29) (Cancer/testis antigen 73) (CT73)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAM29 in