DegronMD

Uniprot ID: Q9UKF5

Source protein: Disintegrin and metalloproteinase domain-containing protein 29

Source gene: ADAM29

Class: DEG_SCF_FBW7_1

Location: 761:768

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 89.175

COIL: 0.9698

CONS_SCORE: 0.5303

DSS_SCORE: 0.8629

HELIX: 0.0136

FCONS_SCORE: 1.195

RIG_SCORE: 0.5091

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V763L	TCGA-19-5955	GBM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.5654
p.V763L	DO12208	GBM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.5654
p.P762L	TCGA-AX-A06F	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.6471
p.P762L	DO41752	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.6471
p.R771W	TCGA-AZ-6598	COAD	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.25
p.R771W	DO10276	COAD	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.25
p.S757F	TCGA-D3-A3MV	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.2222
p.S757F	DO37727	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.2222
p.P762S	TCGA-EE-A2GB	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.5641
p.P762S	DO222683	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.5641
p.P762S	DO37417	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.5641
p.P762A	TCGA-ZF-A9RL	BLCA	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.6392
p.P762A	DO219078	BLCA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.6392
p.M773T	DO222869	COCA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.1944
p.M773T	DO48746	LIRI	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.1944
p.M773T	DO48703	LIRI	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.1944
p.P770H	DO233903	GACA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.2778
p.S768R	DO228900	LICA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.7427
p.V754M	DO220877	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.1389
p.P765L	DO220898	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.7582
p.S759R	SIDM01276	Colorectal Carcinoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	0.2778
p.P752S	SIDM01060	Melanoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	0.0833
p.P752S	ACH-000882	Skin Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.0833
p.P752S	IGR-1	skin	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	0.0833
p.P774H	SIDM00878	Breast Carcinoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	0.1667
p.P774H	ACH-000930	Breast Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.1667
p.P774H	HCC1569	breast	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	0.1667
p.P762H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.6583
p.P762H	MFE-319	endometrium	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	0.6583
p.P752L	ACH-002396	Bone Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.0833
p.P752L	Sarc9371	bone	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVTPSQS

Degron related mutations and impact score

Drug responses associated with ADAM29 mutations

All proteins holding degron of PPVTPSQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKF5	Disintegrin and metalloproteinase domain-containing protein 29	DEG_SCF_FBW7_1	743:750	PPVTPSQS	FBXW7	0.8406	More...
Q9UKF5	Disintegrin and metalloproteinase domain-containing protein 29	DEG_SCF_FBW7_1	761:768	PPVTPSQS	FBXW7	0.9944	More...