DegronMD

Uniprot ID: Q9UKF5

Source protein: Disintegrin and metalloproteinase domain-containing protein 29

Source gene: ADAM29

Class: DEG_SCF_FBW7_1

Location: 743:750

E3 ligase: FBXW7

DEGRON score: 0.8406

ASA_SCORE: 92.5875

COIL: 0.9634

CONS_SCORE: 0.435

DSS_SCORE: 0.8266

HELIX: 0.0211

FCONS_SCORE: 0.9631

RIG_SCORE: 0.4925

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T746M	TCGA-33-4589	LUSC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.7423
p.T746M	DO6370	CLLE	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.7423
p.T746M	DO48292	ESCA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.7423
p.T746M	DO26623	LUSC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.7423
p.T746M	ACH-000765	Skin Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.7423
p.T746M	ACH-002014	Eye Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.7423
p.Q742L	TCGA-92-8063	LUSC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.3056
p.Q742L	DO26941	LUSC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.3056
p.Q749H	TCGA-AP-A051	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.647
p.Q749H	DO42673	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.647
p.P747L	TCGA-BF-A1Q0	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.7582
p.P747L	DO47374	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.7582
p.P744H	TCGA-BK-A6W3	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.6583
p.P744H	DO50076	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.6583
p.S757F	TCGA-D3-A3MV	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.1389
p.S757F	DO37727	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.1389
p.Q749L	TCGA-E6-A1LX	UCEC	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.6654
p.Q749L	DO41020	UCEC	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.6654
p.P734T	TCGA-FC-A8O0	PRAD	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.0833
p.P734T	DO49765	PRAD	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.0833
p.P743S	TCGA-FS-A4F5	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.6752
p.P743S	DO37881	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.6752
p.S739F	TCGA-GF-A6C9	SKCM	TCGA	PPVTPSQS	DEG_SCF_FBW7_1	0.2222
p.S739F	DO51254	SKCM	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.2222
p.V754M	DO220877	MELA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.2222
p.Q733E	DO34608	PACA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.0556
p.S750R	DO47171	RECA	ICGC	PPVTPSQS	DEG_SCF_FBW7_1	0.7427
p.S759R	SIDM01276	Colorectal Carcinoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	0.0833
p.P752S	SIDM01060	Melanoma	GDSC	PPVTPSQS	DEG_SCF_FBW7_1	0.2778
p.P752S	ACH-000882	Skin Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.2778
p.P752S	IGR-1	skin	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	0.2778
p.P752L	ACH-002396	Bone Cancer	CCLE	PPVTPSQS	DEG_SCF_FBW7_1	0.2778
p.P752L	Sarc9371	bone	COSMIC	PPVTPSQS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVTPSQS

Degron related mutations and impact score

Drug responses associated with ADAM29 mutations

All proteins holding degron of PPVTPSQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKF5	Disintegrin and metalloproteinase domain-containing protein 29	DEG_SCF_FBW7_1	743:750	PPVTPSQS	FBXW7	0.8406	More...
Q9UKF5	Disintegrin and metalloproteinase domain-containing protein 29	DEG_SCF_FBW7_1	761:768	PPVTPSQS	FBXW7	0.9944	More...