DegronMD

Uniprot ID: Q9NXL9

Source protein: DNA helicase MCM9

Source gene: MCM9

Class: DEG_SCF_FBW7_1

Location: 876:883

E3 ligase: FBXW7

DEGRON score: 0.9697

ASA_SCORE: 91.7875

COIL: 0.9549

CONS_SCORE: 0.2429

DSS_SCORE: 0.7061

HELIX: 0.0188

FCONS_SCORE: 1.007

RIG_SCORE: 0.5716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M887R	DO229010	COCA	ICGC	PQSTPVHS	DEG_SCF_FBW7_1	0.2222
p.S874F	DO220886	MELA	ICGC	PQSTPVHS	DEG_SCF_FBW7_1	0.2778
p.D885N	SIDM01146	Gastric Carcinoma	GDSC	PQSTPVHS	DEG_SCF_FBW7_1	0.2778
p.D885N	ACH-000932	Gastric Cancer	CCLE	PQSTPVHS	DEG_SCF_FBW7_1	0.2778
p.D885N	NCI-SNU-1	stomach	COSMIC	PQSTPVHS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXL9	DNA helicase MCM9	DEG_SCF_FBW7_1	876:883	PQSTPVHS	FBXW7	0.9697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons