DegronMD - Q9NXL9(MCM9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1097C	TCGA-D5-6530	COAD	TCGA	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.2222
p.R1097C	DO8312	COAD	ICGC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.2222
p.M887R	DO229010	COCA	ICGC	PQSTPVHS	DEG_SCF_FBW7_1	876:883	Mutation rewiring degron network	0.2222
p.S1087I	DO233179	GACA	ICGC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation blocking phosphorylation signal	0.7222
p.R1097H	DO233272	GACA	ICGC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.2222
p.P1089T	DO228978	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation altering degron motif	0.7031
p.S874F	DO220886	MELA	ICGC	PQSTPVHS	DEG_SCF_FBW7_1	876:883	Mutation rewiring degron network	0.2778
p.G1082D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1389
p.G1082D	ACH-000893	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1389
p.G1082D	NCI-H1651	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1389
p.T1091I	SIDM00683	Prostate Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation altering degron motif	0.7078
p.T1091I	ACH-000977	lymph node	CCLE	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation altering degron motif	0.7078
p.T1091I	LNCaP-Clone-FGC	prostate	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation altering degron motif	0.7078
p.D885N	SIDM01146	Gastric Carcinoma	GDSC	PQSTPVHS	DEG_SCF_FBW7_1	876:883	Mutation rewiring degron network	0.2778
p.D885N	ACH-000932	Gastric Cancer	CCLE	PQSTPVHS	DEG_SCF_FBW7_1	876:883	Mutation rewiring degron network	0.2778
p.D885N	NCI-SNU-1	stomach	COSMIC	PQSTPVHS	DEG_SCF_FBW7_1	876:883	Mutation rewiring degron network	0.2778
p.P1086S	SIDM00217	Colorectal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.P1086S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.P1086S	SNU-1040	large intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.S1103Y	SIDM00118	Colorectal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation blocking phosphorylation signal	0.5
p.S1103Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation blocking phosphorylation signal	0.5
p.S1103Y	HCC2998	large intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation blocking phosphorylation signal	0.5
p.G1082S	SIDM00515	Melanoma	GDSC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1389
p.G1082S	ACH-000401	Skin Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1389
p.G1082S	ACH-001339	Skin Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1389
p.G1082S	COLO-800	skin	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1389
p.R1081Q	ACH-001664	Gastric Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1111
p.M1096V	H2722	pleura	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.M1096V	SU8686	pancreas	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.M1096V	A2058	skin	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.M1096V	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.M1096V	SK-MEL-24	skin	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.R1084K	LoVo	large intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.1944

Kaplan plot for MCM9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM9

UniProt ID: Q9NXL9

Entrez ID: 254394

Protein name: DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM9 in