DegronMD

Uniprot ID: Q9NXL9

Source protein: DNA helicase MCM9

Source gene: MCM9

Class: DEG_SPOP_SBC_1

Location: 1089:1093

E3 ligase: SPOP

DEGRON score: 0.6174

ASA_SCORE: 87.3

COIL: 0.9252

CONS_SCORE: 0.2084

DSS_SCORE: 0.7898

HELIX: 0.0414

FCONS_SCORE: 0.9296

RIG_SCORE: 0.5588

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1097C	TCGA-D5-6530	COAD	TCGA	PPTTT	DEG_SPOP_SBC_1	0.2222
p.R1097C	DO8312	COAD	ICGC	PPTTT	DEG_SPOP_SBC_1	0.2222
p.S1087I	DO233179	GACA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.7222
p.R1097H	DO233272	GACA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.2222
p.P1089T	DO228978	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.7031
p.G1082D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	0.1389
p.G1082D	ACH-000893	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	0.1389
p.G1082D	NCI-H1651	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.1389
p.T1091I	SIDM00683	Prostate Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	0.7078
p.T1091I	ACH-000977	lymph_node	CCLE	PPTTT	DEG_SPOP_SBC_1	0.7078
p.T1091I	LNCaP-Clone-FGC	prostate	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.7078
p.P1086S	SIDM00217	Colorectal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	0.25
p.P1086S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	0.25
p.P1086S	SNU-1040	large_intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.25
p.S1103Y	SIDM00118	Colorectal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	0.5
p.S1103Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	0.5
p.S1103Y	HCC2998	large_intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.5
p.G1082S	SIDM00515	Melanoma	GDSC	PPTTT	DEG_SPOP_SBC_1	0.1389
p.G1082S	ACH-000401	Skin Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	0.1389
p.G1082S	ACH-001339	Skin Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	0.1389
p.G1082S	COLO-800	skin	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.1389
p.R1081Q	ACH-001664	Gastric Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	0.1111
p.M1096V	H2722	pleura	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.25
p.M1096V	SU8686	pancreas	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.25
p.M1096V	A2058	skin	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.25
p.M1096V	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.25
p.M1096V	SK-MEL-24	skin	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.25
p.R1084K	LoVo	large_intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	410:414	PPTTT	SPOP	0.9659	More...
P06127	T-cell surface glycoprotein CD5	DEG_SPOP_SBC_1	146:150	PPTTT	SPOP	0.7038	More...
P14780	Matrix metalloproteinase-9	DEG_SPOP_SBC_1	453:457	PPTTT	SPOP	0.9889	More...
P49336	Cyclin-dependent kinase 8	DEG_SPOP_SBC_1	408:412	PPTTT	SPOP	0.9916	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1401:1405	PPTTT	SPOP	0.6712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1417:1421	PPTTT	SPOP	0.7768	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1424:1428	PPTTT	SPOP	0.5001	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1433:1437	PPTTT	SPOP	0.9489	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1472:1476	PPTTT	SPOP	0.5727	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1518:1522	PPTTT	SPOP	0.6668	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1534:1538	PPTTT	SPOP	0.875	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1541:1545	PPTTT	SPOP	0.8682	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1557:1561	PPTTT	SPOP	0.9028	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1573:1577	PPTTT	SPOP	0.6471	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1613:1617	PPTTT	SPOP	0.6161	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1620:1624	PPTTT	SPOP	0.9877	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1636:1640	PPTTT	SPOP	0.8931	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1644:1648	PPTTT	SPOP	0.6445	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1676:1680	PPTTT	SPOP	0.8968	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1691:1695	PPTTT	SPOP	0.728	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1748:1752	PPTTT	SPOP	0.7782	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1895:1899	PPTTT	SPOP	0.5416	More...
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_SPOP_SBC_1	675:679	PPTTT	SPOP	0.9953	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	419:423	PPTTT	SPOP	0.9988	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1446:1450	PPTTT	SPOP	0.9943	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1572:1576	PPTTT	SPOP	0.9457	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	641:645	PPTTT	SPOP	0.9938	More...
Q76M96	Coiled-coil domain-containing protein 80	DEG_SPOP_SBC_1	396:400	PPTTT	SPOP	0.9674	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	611:615	PPTTT	SPOP	0.92	More...
Q8TEQ8	GPI ethanolamine phosphate transferase 3	DEG_SPOP_SBC_1	127:131	PPTTT	SPOP	0.564	More...
Q9NP99	Triggering receptor expressed on myeloid cells 1	DEG_SPOP_SBC_1	155:159	PPTTT	SPOP	0.9954	More...
Q9NQS3	Nectin-3	DEG_SPOP_SBC_1	358:362	PPTTT	SPOP	0.9785	More...
Q9NXL9	DNA helicase MCM9	DEG_SPOP_SBC_1	1089:1093	PPTTT	SPOP	0.6174	More...
Q9NYY3	Serine/threonine-protein kinase PLK2	DEG_SPOP_SBC_1	422:426	PPTTT	SPOP	0.8683	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	65:69	PPTTT	SPOP	0.991	More...
A1L1A6	Immunoglobulin superfamily member 23	DEG_SPOP_SBC_1	19:23	PPTTT	SPOP	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTT

Degron related mutations and impact score

Drug responses associated with MCM9 mutations

All proteins holding degron of PPTTT