DegronMD

Uniprot ID: Q9NYY3

Source protein: Serine/threonine-protein kinase PLK2

Source gene: PLK2

Class: DEG_SPOP_SBC_1

Location: 422:426

E3 ligase: SPOP

DEGRON score: 0.8683

ASA_SCORE: 89.32

COIL: 0.899

CONS_SCORE: 0.3192

DSS_SCORE: 0.7077

HELIX: 0.0674

FCONS_SCORE: 1.1309

RIG_SCORE: 0.6765

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A428T	TCGA-A5-A0G1	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	0.2778
p.A428T	DO42472	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	0.2778
p.S430F	TCGA-ET-A39O	THCA	TCGA	PPTTT	DEG_SPOP_SBC_1	0.2222
p.S430F	DO39874	THCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.2222
p.V435I	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	0.0833
p.V427I	ACH-001737	Leukemia	CCLE	PPTTT	DEG_SPOP_SBC_1	0.3056
p.R432Q	HCT-15	large_intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.1667

Drug responses associated with PLK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00537	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	0.0263
SIDM00213	THCA\|thyroid	p.S163R (No)	GDSC	PLK_6522	0.1012
SIDM00145	ALL\|lymphoblastic_leukemia	p.L603I (No)	GDSC	BI-2536	0.0223
SIDM00145	ALL\|lymphoblastic_leukemia	p.L603I (No)	GDSC	PLK_6522	0.0104
SIDM00454	UNCLASSIFIED\|rhabdomyosarcoma	p.S63W (No)	GDSC	PLK_6522	0.5713
SIDM00781	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	BI-2536	0.0109
SIDM00781	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	1.1758
SIDM00881	BRCA\|breast	p.A110T (No)	GDSC	PLK_6522	1.5141
SIDM00881	BRCA\|breast	p.A110T (No)	GDSC	BI-2536	3.0073
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H385Y (No)	GDSC	BI-2536	0.2197
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H385Y (No)	GDSC	PLK_6522	0.1344
SIDM01051	UNCLASSIFIED\|ovary	p.R296K (No)	GDSC	PLK_6522	0.1367
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G587V (No)	GDSC	PLK_6522	0.023
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.L335fs*68 (No)	GDSC	PLK_6522	0.0206
SIDM00151	OV\|ovary	p.L335fs*68 (No)	GDSC	PLK_6522	12.2409
SIDM00373	UCEC\|endometrium	p.L335fs*68 (No)	GDSC	PLK_6522	0.0129
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.R164T (No)	GDSC	BI-2536	0.3472
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.R164T (No)	GDSC	PLK_6522	0.0578
SIDM00630	BRCA\|breast	p.D628N (No)	GDSC	PLK_6522	0.7349
SIDM00630	BRCA\|breast	p.D628N (No)	GDSC	BI-2536	10.987
SIDM00630	BRCA\|breast	p.D392H (No)	GDSC	PLK_6522	0.7349
SIDM00630	BRCA\|breast	p.D392H (No)	GDSC	BI-2536	10.987
SIDM00405	DLBC\|B_cell_lymphoma	p.I329M (No)	GDSC	BI-2536	0.0473
SIDM00405	DLBC\|B_cell_lymphoma	p.I329M (No)	GDSC	PLK_6522	1.944
SIDM00140	SKCM\|melanoma	p.P319S (No)	GDSC	PLK_6522	0.1346
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.D594G (No)	GDSC	BI-2536	0.1271
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.D594G (No)	GDSC	PLK_6522	0.1001
SIDM00839	COREAD\|large_intestine	p.S636N (No)	GDSC	PLK_6522	0.0606
SIDM00282	COREAD\|large_intestine	p.D560V (No)	GDSC	BI-2536	7.519
SIDM00282	COREAD\|large_intestine	p.D560V (No)	GDSC	PLK_6522	0.905
SIDM00973	SKCM\|melanoma	p.L643P (No)	GDSC	PLK_6522	0.0318
SIDM00878	BRCA\|breast	p.L335fs*68 (No)	GDSC	PLK_6522	0.4074
SIDM00878	BRCA\|breast	p.L335fs*68 (No)	GDSC	BI-2536	3.8832
SIDM00819	KIRC\|kidney	p.N104S (No)	GDSC	PLK_6522	0.0701
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.L310F (No)	GDSC	BI-2536	0.1578
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.L310F (No)	GDSC	PLK_6522	0.1099
SIDM00789	COREAD\|large_intestine	p.R446Q (No)	GDSC	PLK_6522	4.2953
SIDM00534	COREAD\|large_intestine	p.R672* (No)	GDSC	PLK_6522	0.1358
SIDM00680	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	0.4107
SIDM00217	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	1.7973
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I651V (No)	GDSC	BI-2536	0.0224
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I651V (No)	GDSC	PLK_6522	0.8422
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.Q409R (No)	GDSC	BI-2536	0.0418
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.Q409R (No)	GDSC	PLK_6522	0.055
SIDM00537	COREAD\|large_intestine	p.Y546C (No)	GDSC	PLK_6522	0.0263
SIDM00410	ALL\|lymphoid_neoplasm_other	p.H545N (No)	GDSC	BI-2536	2.1317
SIDM00410	ALL\|lymphoid_neoplasm_other	p.H545N (No)	GDSC	PLK_6522	1.9143
SIDM00657	UNCLASSIFIED\|leukemia	p.H60D (No)	GDSC	BI-2536	0.0684
SIDM00657	UNCLASSIFIED\|leukemia	p.H60D (No)	GDSC	PLK_6522	0.0187
SIDM00193	COREAD\|large_intestine	p.R672* (No)	GDSC	PLK_6522	0.2636
SIDM00118	COREAD\|large_intestine	p.R330Q (No)	GDSC	PLK_6522	0.0186
SIDM01109	UNCLASSIFIED\|soft_tissue_other	p.M468T (No)	GDSC	BI-2536	0.0441
SIDM01109	UNCLASSIFIED\|soft_tissue_other	p.M468T (No)	GDSC	PLK_6522	0.0183

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	410:414	PPTTT	SPOP	0.9659	More...
P06127	T-cell surface glycoprotein CD5	DEG_SPOP_SBC_1	146:150	PPTTT	SPOP	0.7038	More...
P14780	Matrix metalloproteinase-9	DEG_SPOP_SBC_1	453:457	PPTTT	SPOP	0.9889	More...
P49336	Cyclin-dependent kinase 8	DEG_SPOP_SBC_1	408:412	PPTTT	SPOP	0.9916	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1401:1405	PPTTT	SPOP	0.6712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1417:1421	PPTTT	SPOP	0.7768	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1424:1428	PPTTT	SPOP	0.5001	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1433:1437	PPTTT	SPOP	0.9489	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1472:1476	PPTTT	SPOP	0.5727	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1518:1522	PPTTT	SPOP	0.6668	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1534:1538	PPTTT	SPOP	0.875	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1541:1545	PPTTT	SPOP	0.8682	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1557:1561	PPTTT	SPOP	0.9028	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1573:1577	PPTTT	SPOP	0.6471	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1613:1617	PPTTT	SPOP	0.6161	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1620:1624	PPTTT	SPOP	0.9877	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1636:1640	PPTTT	SPOP	0.8931	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1644:1648	PPTTT	SPOP	0.6445	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1676:1680	PPTTT	SPOP	0.8968	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1691:1695	PPTTT	SPOP	0.728	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1748:1752	PPTTT	SPOP	0.7782	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1895:1899	PPTTT	SPOP	0.5416	More...
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_SPOP_SBC_1	675:679	PPTTT	SPOP	0.9953	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	419:423	PPTTT	SPOP	0.9988	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1446:1450	PPTTT	SPOP	0.9943	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1572:1576	PPTTT	SPOP	0.9457	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	641:645	PPTTT	SPOP	0.9938	More...
Q76M96	Coiled-coil domain-containing protein 80	DEG_SPOP_SBC_1	396:400	PPTTT	SPOP	0.9674	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	611:615	PPTTT	SPOP	0.92	More...
Q8TEQ8	GPI ethanolamine phosphate transferase 3	DEG_SPOP_SBC_1	127:131	PPTTT	SPOP	0.564	More...
Q9NP99	Triggering receptor expressed on myeloid cells 1	DEG_SPOP_SBC_1	155:159	PPTTT	SPOP	0.9954	More...
Q9NQS3	Nectin-3	DEG_SPOP_SBC_1	358:362	PPTTT	SPOP	0.9785	More...
Q9NXL9	DNA helicase MCM9	DEG_SPOP_SBC_1	1089:1093	PPTTT	SPOP	0.6174	More...
Q9NYY3	Serine/threonine-protein kinase PLK2	DEG_SPOP_SBC_1	422:426	PPTTT	SPOP	0.8683	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	65:69	PPTTT	SPOP	0.991	More...
A1L1A6	Immunoglobulin superfamily member 23	DEG_SPOP_SBC_1	19:23	PPTTT	SPOP	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTT

Degron related mutations and impact score

Drug responses associated with PLK2 mutations

All proteins holding degron of PPTTT