DegronMD

Uniprot ID: Q9NYY3

Source protein: Serine/threonine-protein kinase PLK2

Source gene: PLK2

Class: DEG_SPOP_SBC_1

Location: 422:426

E3 ligase: SPOP

DEGRON score: 0.8683

ASA_SCORE: 89.32

COIL: 0.899

CONS_SCORE: 0.3192

DSS_SCORE: 0.7077

HELIX: 0.0674

FCONS_SCORE: 1.1309

RIG_SCORE: 0.6765

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V427I	ACH-001737	Leukemia	CCLE	PPTTT	DEG_SPOP_SBC_1	0.3056
p.A428T	TCGA-A5-A0G1	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	0.2778
p.A428T	DO42472	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	0.2778
p.S430F	TCGA-ET-A39O	THCA	TCGA	PPTTT	DEG_SPOP_SBC_1	0.2222
p.S430F	DO39874	THCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.2222
p.R432Q	HCT-15	large_intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	0.1667
p.V435I	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	0.0833

Showing 1 to 7 of 7 entries

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Drug responses associated with PLK2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00145	ALL\|lymphoblastic_leukemia	p.L603I (No)	GDSC	BI-2536	0.0223
SIDM00145	ALL\|lymphoblastic_leukemia	p.L603I (No)	GDSC	PLK_6522	0.0104
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I651V (No)	GDSC	BI-2536	0.0224
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I651V (No)	GDSC	PLK_6522	0.8422
SIDM00410	ALL\|lymphoid_neoplasm_other	p.H545N (No)	GDSC	BI-2536	2.1317
SIDM00410	ALL\|lymphoid_neoplasm_other	p.H545N (No)	GDSC	PLK_6522	1.9143
SIDM00881	BRCA\|breast	p.A110T (No)	GDSC	PLK_6522	1.5141
SIDM00881	BRCA\|breast	p.A110T (No)	GDSC	BI-2536	3.0073
SIDM00630	BRCA\|breast	p.D628N (No)	GDSC	PLK_6522	0.7349
SIDM00630	BRCA\|breast	p.D628N (No)	GDSC	BI-2536	10.987
SIDM00630	BRCA\|breast	p.D392H (No)	GDSC	PLK_6522	0.7349
SIDM00630	BRCA\|breast	p.D392H (No)	GDSC	BI-2536	10.987
SIDM00878	BRCA\|breast	p.L335fs*68 (No)	GDSC	PLK_6522	0.4074
SIDM00878	BRCA\|breast	p.L335fs*68 (No)	GDSC	BI-2536	3.8832
SIDM00537	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	0.0263
SIDM00781	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	BI-2536	0.0109
SIDM00781	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	1.1758
SIDM00839	COREAD\|large_intestine	p.S636N (No)	GDSC	PLK_6522	0.0606
SIDM00282	COREAD\|large_intestine	p.D560V (No)	GDSC	BI-2536	7.519
SIDM00282	COREAD\|large_intestine	p.D560V (No)	GDSC	PLK_6522	0.905
SIDM00789	COREAD\|large_intestine	p.R446Q (No)	GDSC	PLK_6522	4.2953
SIDM00534	COREAD\|large_intestine	p.R672* (No)	GDSC	PLK_6522	0.1358
SIDM00680	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	0.4107
SIDM00217	COREAD\|large_intestine	p.L335fs*68 (No)	GDSC	PLK_6522	1.7973
SIDM00537	COREAD\|large_intestine	p.Y546C (No)	GDSC	PLK_6522	0.0263

Showing 1 to 25 of 53 entries

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All proteins holding degron of PPTTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	410:414	PPTTT	SPOP	0.9659	More...
Q76M96	Coiled-coil domain-containing protein 80	DEG_SPOP_SBC_1	396:400	PPTTT	SPOP	0.9674	More...
P49336	Cyclin-dependent kinase 8	DEG_SPOP_SBC_1	408:412	PPTTT	SPOP	0.9916	More...
Q9NXL9	DNA helicase MCM9	DEG_SPOP_SBC_1	1089:1093	PPTTT	SPOP	0.6174	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	419:423	PPTTT	SPOP	0.9988	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1446:1450	PPTTT	SPOP	0.9943	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1572:1576	PPTTT	SPOP	0.9457	More...
Q8TEQ8	GPI ethanolamine phosphate transferase 3	DEG_SPOP_SBC_1	127:131	PPTTT	SPOP	0.564	More...
A1L1A6	Immunoglobulin superfamily member 23	DEG_SPOP_SBC_1	19:23	PPTTT	SPOP	0.989	More...
P14780	Matrix metalloproteinase-9	DEG_SPOP_SBC_1	453:457	PPTTT	SPOP	0.9889	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	65:69	PPTTT	SPOP	0.991	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1401:1405	PPTTT	SPOP	0.6712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1417:1421	PPTTT	SPOP	0.7768	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1424:1428	PPTTT	SPOP	0.5001	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1433:1437	PPTTT	SPOP	0.9489	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1472:1476	PPTTT	SPOP	0.5727	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1518:1522	PPTTT	SPOP	0.6668	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1534:1538	PPTTT	SPOP	0.875	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1541:1545	PPTTT	SPOP	0.8682	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1557:1561	PPTTT	SPOP	0.9028	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1573:1577	PPTTT	SPOP	0.6471	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1613:1617	PPTTT	SPOP	0.6161	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1620:1624	PPTTT	SPOP	0.9877	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1636:1640	PPTTT	SPOP	0.8931	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1644:1648	PPTTT	SPOP	0.6445	More...

Showing 1 to 25 of 36 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTT

Degron related mutations and impact score

Drug responses associated with PLK2 mutations

All proteins holding degron of PPTTT