DegronMD - Q8TEQ8(PIGO)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P308H	TCGA-18-3407	LUSC	TCGA	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation altering degron motif	0.7694
p.P308H	DO26454	LUSC	ICGC	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation altering degron motif	0.7694
p.T130A	TCGA-63-A5MP	LUSC	TCGA	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7139
p.T130A	DO219157	LUSC	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7139
p.A305S	TCGA-AJ-A3EL	UCEC	TCGA	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.25
p.A305S	DO41542	UCEC	ICGC	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.25
p.R122Q	TCGA-AJ-A3EL	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.R122Q	DO41542	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.R119Q	TCGA-AJ-A3OJ	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	TCGA-AP-A1E1	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	DO43226	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	DO42753	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	SIDM00296	Small Cell Lung Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	ACH-000241	Leukemia	CCLE	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	ACH-002051	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R119Q	LU-134-A	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.R79Q	TCGA-B5-A0JY	UCEC	TCGA	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.25
p.R79Q	TCGA-KN-8428	KICH	TCGA	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.25
p.R79Q	DO220484	KICH	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.25
p.R79Q	DO43041	UCEC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.25
p.R66Q	TCGA-EO-A22U	UCEC	TCGA	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.R66Q	DO227844	COCA	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.R66Q	DO231149	LUSC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.R66Q	DO43755	UCEC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.P319T	TCGA-ER-A19F	SKCM	TCGA	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.1944
p.P319T	DO37679	SKCM	ICGC	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.1944
p.Y301C	TCGA-J4-A67M	PRAD	TCGA	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.1389
p.Y301C	DO48658	PRAD	ICGC	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.1389
p.P58T	DO228978	LICA	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.0556
p.A137D	DO229027	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1667
p.A64D	DO229006	LICA	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2222
p.Q133K	DO229009	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.R134H	DO45299	LIRI	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.25
p.R134H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.25
p.R134H	ACH-000981	Leukemia	CCLE	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.25
p.R134H	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.25
p.L78V	DO230536	LUSC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2778
p.L120I	DO33912	PACA	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1389
p.A118S	DO229396	PRAD	ICGC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.P128L	SIDM01277	Esophageal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.6471
p.S302C	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.1667
p.S302C	ACH-000521	Lung Cancer	CCLE	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.1667
p.S302C	NCI-H2030	lung	COSMIC	PSTPPEE	DEG_SCF_FBW7_2	308:314	Mutation rewiring degron network	0.1667
p.P128S	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5641
p.P128S	ACH-002077	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5641
p.P128S	LU-165	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5641
p.A83T	SIDM01608	Endometrial Carcinoma	GDSC	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1389
p.A83T	ACH-000990	Endometrial/Uterine Cancer	CCLE	SRVVLVLID	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIGO

UniProt ID: Q8TEQ8

Entrez ID: 84720

Protein name: GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIGO in