DegronMD

Uniprot ID: Q8TEQ8

Source protein: GPI ethanolamine phosphate transferase 3

Source gene: PIGO

Class: DEG_SCF_FBW7_2

Location: 308:314

E3 ligase: FBXW7

DEGRON score: 0.5969

ASA_SCORE: 95.4286

COIL: 0.9624

CONS_SCORE: 0.3153

DSS_SCORE: 0.4137

HELIX: 0.0181

FCONS_SCORE: 0.5927

RIG_SCORE: 0.6759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P308H	TCGA-18-3407	LUSC	TCGA	PSTPPEE	DEG_SCF_FBW7_2	0.7694
p.P308H	DO26454	LUSC	ICGC	PSTPPEE	DEG_SCF_FBW7_2	0.7694
p.A305S	TCGA-AJ-A3EL	UCEC	TCGA	PSTPPEE	DEG_SCF_FBW7_2	0.25
p.A305S	DO41542	UCEC	ICGC	PSTPPEE	DEG_SCF_FBW7_2	0.25
p.P319T	TCGA-ER-A19F	SKCM	TCGA	PSTPPEE	DEG_SCF_FBW7_2	0.1944
p.P319T	DO37679	SKCM	ICGC	PSTPPEE	DEG_SCF_FBW7_2	0.1944
p.Y301C	TCGA-J4-A67M	PRAD	TCGA	PSTPPEE	DEG_SCF_FBW7_2	0.1389
p.Y301C	DO48658	PRAD	ICGC	PSTPPEE	DEG_SCF_FBW7_2	0.1389
p.S302C	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PSTPPEE	DEG_SCF_FBW7_2	0.1667
p.S302C	ACH-000521	Lung Cancer	CCLE	PSTPPEE	DEG_SCF_FBW7_2	0.1667
p.S302C	NCI-H2030	lung	COSMIC	PSTPPEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEQ8	GPI ethanolamine phosphate transferase 3	DEG_SCF_FBW7_2	308:314	PSTPPEE	FBXW7	0.5969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons