DegronMD

Uniprot ID: Q8TEQ8

Source protein: GPI ethanolamine phosphate transferase 3

Source gene: PIGO

Class: DEG_APCC_DBOX_1

Location: 68:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6083

ASA_SCORE: 14.6222

COIL: 0.2127

CONS_SCORE: 0.6169

DSS_SCORE: 0.0361

HELIX: 0.0159

FCONS_SCORE: 1.3012

RIG_SCORE: 0.9479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R79Q	TCGA-B5-A0JY	UCEC	TCGA	SRVVLVLID	DEG_APCC_DBOX_1	0.25
p.R79Q	TCGA-KN-8428	KICH	TCGA	SRVVLVLID	DEG_APCC_DBOX_1	0.25
p.R79Q	DO220484	KICH	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.25
p.R79Q	DO43041	UCEC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.25
p.R66Q	TCGA-EO-A22U	UCEC	TCGA	SRVVLVLID	DEG_APCC_DBOX_1	0.2778
p.R66Q	DO227844	COCA	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.2778
p.R66Q	DO231149	LUSC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.2778
p.R66Q	DO43755	UCEC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.2778
p.P58T	DO228978	LICA	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.0556
p.A64D	DO229006	LICA	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.2222
p.L78V	DO230536	LUSC	ICGC	SRVVLVLID	DEG_APCC_DBOX_1	0.2778
p.A83T	SIDM01608	Endometrial Carcinoma	GDSC	SRVVLVLID	DEG_APCC_DBOX_1	0.1389
p.A83T	ACH-000990	Endometrial/Uterine Cancer	CCLE	SRVVLVLID	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEQ8	GPI ethanolamine phosphate transferase 3	DEG_APCC_DBOX_1	68:76	SRVVLVLID	APC,CDC20,FZR1	0.6083	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons