DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SPOP_SBC_1

Location: 1676:1680

E3 ligase: SPOP

DEGRON score: 0.8968

ASA_SCORE: 103.1

COIL: 0.963

CONS_SCORE: 0.3156

DSS_SCORE: 0.7803

HELIX: 0.009

FCONS_SCORE: 1.0747

RIG_SCORE: 0.5613

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1678A	DO222874	COCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.7503
p.P1676S	DO229029	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.6752
p.P1676S	DO229006	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.6752
p.P1675L	DO224739	COCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.3056
p.P1675T	DO222571	COCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.3056
p.P1675T	DO49531	LAML	ICGC	PPTTT	DEG_SPOP_SBC_1	0.3056
p.P1675T	DO229024	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.3056
p.P1675T	DO229006	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.3056
p.G1682D	DO41241	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	0.2778
p.T1683M	DO224661	COCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.25
p.T1683M	DO224801	COCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.25
p.T1683M	DO232594	PBCA	ICGC	PPTTT	DEG_SPOP_SBC_1	0.25
p.P1673L	DO50987	LAML	ICGC	PPTTT	DEG_SPOP_SBC_1	0.25
p.P1667A	TCGA-BH-A208	BRCA	TCGA	PPTTT	DEG_SPOP_SBC_1	0.0833
p.P1690H	TCGA-PK-A5HB	ACC	TCGA	PPTTT	DEG_SPOP_SBC_1	0.0556
p.P1690L	DO38187	STAD	ICGC	PPTTT	DEG_SPOP_SBC_1	0.0556

Showing 1 to 16 of 16 entries

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Drug responses associated with MUC2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPTTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	410:414	PPTTT	SPOP	0.9659	More...
Q76M96	Coiled-coil domain-containing protein 80	DEG_SPOP_SBC_1	396:400	PPTTT	SPOP	0.9674	More...
P49336	Cyclin-dependent kinase 8	DEG_SPOP_SBC_1	408:412	PPTTT	SPOP	0.9916	More...
Q9NXL9	DNA helicase MCM9	DEG_SPOP_SBC_1	1089:1093	PPTTT	SPOP	0.6174	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	419:423	PPTTT	SPOP	0.9988	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1446:1450	PPTTT	SPOP	0.9943	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1572:1576	PPTTT	SPOP	0.9457	More...
Q8TEQ8	GPI ethanolamine phosphate transferase 3	DEG_SPOP_SBC_1	127:131	PPTTT	SPOP	0.564	More...
A1L1A6	Immunoglobulin superfamily member 23	DEG_SPOP_SBC_1	19:23	PPTTT	SPOP	0.989	More...
P14780	Matrix metalloproteinase-9	DEG_SPOP_SBC_1	453:457	PPTTT	SPOP	0.9889	More...
P43366	Melanoma-associated antigen B1	DEG_SPOP_SBC_1	65:69	PPTTT	SPOP	0.991	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1401:1405	PPTTT	SPOP	0.6712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1417:1421	PPTTT	SPOP	0.7768	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1424:1428	PPTTT	SPOP	0.5001	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1433:1437	PPTTT	SPOP	0.9489	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1472:1476	PPTTT	SPOP	0.5727	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1518:1522	PPTTT	SPOP	0.6668	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1534:1538	PPTTT	SPOP	0.875	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1541:1545	PPTTT	SPOP	0.8682	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1557:1561	PPTTT	SPOP	0.9028	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1573:1577	PPTTT	SPOP	0.6471	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1613:1617	PPTTT	SPOP	0.6161	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1620:1624	PPTTT	SPOP	0.9877	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1636:1640	PPTTT	SPOP	0.8931	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1644:1648	PPTTT	SPOP	0.6445	More...

Showing 1 to 25 of 36 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of PPTTT