DegronMD

Uniprot ID: Q8IZ69

Source protein: tRNA

Source gene: TRMT2A

Class: DEG_SCF_FBW7_2

Location: 575:581

E3 ligase: FBXW7

DEGRON score: 0.6098

ASA_SCORE: 36.6

COIL: 0.7703

CONS_SCORE: 0.7119

DSS_SCORE: 0.1456

HELIX: 0.0039

FCONS_SCORE: 1.4544

RIG_SCORE: 0.8387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q576H	TCGA-D5-6531	COAD	TCGA	PQTPHCE	DEG_SCF_FBW7_2	0.647
p.Q576H	DO7983	COAD	ICGC	PQTPHCE	DEG_SCF_FBW7_2	0.647
p.E587Q	TCGA-ZF-AA51	BLCA	TCGA	PQTPHCE	DEG_SCF_FBW7_2	0.1667
p.E587Q	DO219093	BLCA	ICGC	PQTPHCE	DEG_SCF_FBW7_2	0.1667
p.A571V	SIDM01617	Endometrial Carcinoma	GDSC	PQTPHCE	DEG_SCF_FBW7_2	0.2222
p.P578L	ACH-000955	Colon/Colorectal Cancer	CCLE	PQTPHCE	DEG_SCF_FBW7_2	0.7582
p.P578L	ACH-002296	Head and Neck Cancer	CCLE	PQTPHCE	DEG_SCF_FBW7_2	0.7582
p.P578L	PCI-38	upper_aerodigestive_tract	COSMIC	PQTPHCE	DEG_SCF_FBW7_2	0.7582
p.P578L	SNU-407	large_intestine	COSMIC	PQTPHCE	DEG_SCF_FBW7_2	0.7582
p.E587G	ACH-000975	Lung Cancer	CCLE	PQTPHCE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZ69	tRNA	DEG_SCF_FBW7_2	575:581	PQTPHCE	FBXW7	0.6098	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons