DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1400:1406

E3 ligase: FBXW7

DEGRON score: 0.9751

ASA_SCORE: 104.5

COIL: 0.9306

CONS_SCORE: 0.3276

DSS_SCORE: 0.8149

HELIX: 0.0137

FCONS_SCORE: 1.2914

RIG_SCORE: 0.6086

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1411M	TCGA-AC-A23H	BRCA	TCGA	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411M	DO2401	BRCA	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411M	DO233762	GACA	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411M	SIDM01303	Esophageal Carcinoma	GDSC	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411M	SIDM01650	Non-Cancerous	GDSC	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411K	TCGA-BG-A221	UCEC	TCGA	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411K	TCGA-CD-A4MI	STAD	TCGA	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411K	DO47717	STAD	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411K	DO42384	UCEC	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411S	TCGA-BG-A221	UCEC	TCGA	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.T1411S	DO42384	UCEC	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.1944
p.G1413E	TCGA-EB-A3XC	SKCM	TCGA	PQTPHTT	DEG_SCF_FBW7_1	0.1389
p.G1413E	DO37579	SKCM	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.1389
p.A1412V	DO233865	GACA	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.1667
p.A1412V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PQTPHTT	DEG_SCF_FBW7_1	0.1667
p.A1412V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PQTPHTT	DEG_SCF_FBW7_1	0.1667
p.A1412V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPHTT	DEG_SCF_FBW7_1	0.1667
p.H1404Q	DO224544	LUSC	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.647
p.H1404Q	DO231014	LUSC	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.647
p.T1402P	DO218842	SKCA	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.7031
p.T1402P	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPHTT	DEG_SCF_FBW7_1	0.7031
p.S1408P	DO218842	SKCA	ICGC	PQTPHTT	DEG_SCF_FBW7_1	0.2778
p.T1399A	SIDM00789	Colorectal Carcinoma	GDSC	PQTPHTT	DEG_SCF_FBW7_1	0.3056
p.T1399A	ACH-000997	Colon/Colorectal Cancer	CCLE	PQTPHTT	DEG_SCF_FBW7_1	0.3056
p.T1399A	ACH-001061	Colon/Colorectal Cancer	CCLE	PQTPHTT	DEG_SCF_FBW7_1	0.3056
p.T1399A	HCT-15	large_intestine	COSMIC	PQTPHTT	DEG_SCF_FBW7_1	0.3056
p.T1393R	SIDM00694	Other Solid Cancers	GDSC	PQTPHTT	DEG_SCF_FBW7_1	0.1389
p.G1413R	SIDM01398	Melanoma	GDSC	PQTPHTT	DEG_SCF_FBW7_1	0.1389
p.T1399P	ACH-000999	Colon/Colorectal Cancer	CCLE	PQTPHTT	DEG_SCF_FBW7_1	0.3056
p.T1399P	SNU-1040	large_intestine	COSMIC	PQTPHTT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTPHTT

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of PQTPHTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1400:1406	PQTPHTT	FBXW7	0.9751	More...